双连明目饮治疗肝胆火炽型急性前葡萄膜炎的临床观察  

Clinical observation on treatment of acute anterior uveitis of hepatobiliary fire type with Shuanglian Mingmu Decoction

作　　者：张丹丹 姚靖[2] 孙河[2] 张茜[2] 张宁 牛世煜 ZHANG Dandan;YAO Jing;SUN He;ZHANG Qian;ZHANG Ning;NIU Shiyu(The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150001,China)

机构地区：[1]黑龙江中医药大学附属第二医院,哈尔滨150001 [2]黑龙江中医药大学附属第一医院,哈尔滨150040 [3]大连市妇女儿童医疗中心(集团),大连116011 [4]大连港医院,大连116001

出　　处：《中国中医眼科杂志》2023年第7期627-631,共5页China Journal of Chinese Ophthalmology

基　　金：黑龙江中医药学会青年中医药科技创新项目(ZHY19-030)。

摘　　要：目的观察双连明目饮治疗肝胆火炽型急性前葡萄膜炎的临床疗效。方法纳入2020年10月—2021年10月黑龙江中医药大学附属第一医院眼科诊治的急性前葡萄膜炎患者48例(48只眼)。随机分为治疗组和对照组,每组各24例(24只眼)。对照组予散瞳联合醋酸泼尼松龙滴眼液治疗;治疗组在对照组的基础上联合双连明目饮口服。2组均观察4周。分别于治疗前、治疗后4周检测最佳矫正视力(BCVA)、前房炎症细胞积分、角膜后沉着物(KP)积分和中医证候积分。结果2组治疗前BCVA、前房炎症细胞积分、KP积分和中医证候积分比较,差异均无统计学意义(P>0.05)。(1)BCVA:治疗前后比较,2组治疗后BCVA均较治疗前提高(t_(治疗组)=6.874,t_(对照组)=7.273,均P=0.000)。治疗后2组间比较,治疗组BCVA较对照组提高(t=2.107,P=0.041),差异均有统计学意义。(2)前房炎症细胞积分:治疗前后比较,2组治疗后前房炎症细胞积分均较治疗前降低(t_(治疗组)=13.325,t_(对照组)=12.817,均P=0.000)。治疗后2组间比较,治疗组前房炎症细胞积分较对照组降低(t=2.077,P=0.043),差异均有统计学意义。(3)KP积分:治疗前后比较,2组治疗后KP积分均较治疗前降低(t_(治疗组)=16.265,t_(对照组)=17.442,均P=0.000)。治疗后2组间比较,治疗组KP积分较对照组KP积分降低(t=2.282,P=0.027),差异均有统计学意义。(4)中医证候积分:治疗前后比较,2组治疗后中医证候积分均较治疗前降低(t_(治疗组)=42.402,t_(对照组)=15.389,均P=0.000)。治疗后2组间比较,治疗组中医证候积分较对照组降低(t=10.488,P=0.000),差异均有统计学意义。(5)临床疗效:治疗组显效率(95.83%)高于对照组(41.67%),差异有统计学意义(χ^(2)=16.388,P=0.000)。结论双连明目饮联合治疗肝胆火炽型急性前葡萄膜眼疗效显著,优于单纯西医治疗。OBJECTIVE To observe the clinical efficacy of Shuanglian Mingmu Decoction in the treatment of acute anterior uveitis of hepatobiliary fire type.METHODS A total of 48patients (48 eyes) with acute anterior uveitis were included in the Ophthalmology Department of the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from October 2020 to October 2021.They were randomly divided into the treatment group (TG) and the control group (CG),with 24 cases (24 eyes) in each group.The control group was treated with mydriasis combined with prednisolone acetate eye drops,while the treatment group was treated with Shuanglian Mingmu Decoction orally on the basis of the control group.Both groups were observed for four weeks.The best corrected visual acuity (BCVA),anterior chamber inflammatory cell score,keratic precipitate (KP) score and Traditional Chinese Medicine (TCM)syndrome score were measured before and four weeks after treatment.RESULTS There were no statistically significant differences in BCVA,anterior chamber inflammatory cell scores,posterior corneal KP scores and TCM syndrome scores between the two groups before treatment (P>0.05).(1) BCVA:The BCVA of both groups increased after treatment compared to that before treatment,respectively (t_(TG)=6.874,t_(CG)=7.273,both P=0.000).After treatment,the BCVA of the treatment group was higher than that of the control group (t=2.107,P=0.041),and the difference was statistically significant.(2) Anterior chamber inflammatory cell scores:The anterior chamber inflammatory cell scores in both groups decreased compared to those before treatment (t_(TG)=13.325,t_(CG)=12.817,both P=0.000).After treatment,the anterior chamber inflammatory cell scores of the treatment group were lower than those of the control group (t=2.077,P=0.043),and the differences were statistically significant.(3) Corneal KP scores:The corneal KP scores of both groups decreased after treatment when compared to those before treatment (t_(TG)=16.265,t_(CG)=17.442,both P=0.000).After treatment,the

关 键 词：双连明目饮 肝胆火炽型 急性前葡萄膜炎 

分 类 号：R276.7[医药卫生—中医五官科学]