mTOR自噬相关途径在年龄相关性黄斑变性中的作用及中、西医药物干预进展  

The role of mTOR autophagy pathway in age-related macular degeneration and progress in Traditional Chinese Medicine and Western Medicine intervention

作　　者：郑艺煌 赖佳钰 曹俊昌 胡艳红[2] 陈胜[2] ZHENG Yihuang;LAI Jiayu;CAO Junchang;HU Yanhong;CHEN Sheng(Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China)

机构地区：[1]福建中医药大学,福州350122 [2]福建中医药大学附属第二人民医院,福州350003

出　　处：《中国中医眼科杂志》2023年第7期679-683,共5页China Journal of Chinese Ophthalmology

基　　金：福建省中医药科研项目计划(2021zyjc08)。

摘　　要：年龄相关性黄斑变性(AMD)是一种以玻璃膜疣(Drusen)形成,Bruch膜增厚,脉络膜新生血管(CNV)形成,黄斑区出血、水肿,从而引发视物变形、中心暗点,最终导致不可逆性视力损害为特征的致盲性眼病。其具体发病机制尚未明确,细胞自噬是细胞将不再需要的物质降解和消除的过程,其参与AMD的发病过程,而哺乳动物雷帕霉素靶蛋白(mTOR)在调节细胞自噬中发挥重要的作用。本文从视网膜色素上皮细胞变性、脂褐素沉积和Drusen的形成、CNV及黄斑区纤维瘢痕化的形成等方面阐述mTOR相关自噬参与AMD的机制,并探讨中、西医药物调控自噬以防AMD致盲的可能性。Age-related macular degeneration(AMD) is a blinding eye disease characterized by the formation of drusen,thickening of the Bruch′s membrane,choroidal neovascularization(CNV),hemorrhage,and edema in the macular region,leading to visual distortion,central scotoma,and irreversible vision loss.The specific pathogenic mechanisms of AMD are not yet fully understood,but cellular autophagy,a process by which cells degrade and eliminate unwanted substances,is involved in the development of AMD.The mammalian target of rapamycin(mTOR)plays an important role in regulating cellular autophagy.In this article,we discuss the mechanisms of mTOR-related autophagy involvement in AMD,including retinal pigment epithelial cell degeneration,lipofuscin deposition and drusen formation,CNV,and fibrosis in the macular region.We also explore the possibility of regulating autophagy with Traditional Chinese Medicine and Western Medicine to prevent AMD-related blindness.

关 键 词：年龄相关性黄斑变性 自噬 哺乳动物雷帕霉素靶蛋白 视网膜色素上皮细胞 脉络膜新生血管 

分 类 号：R267.6[医药卫生—中医外科学]