老年高尿酸血症患者血清白细胞介素-23、尿酸、单核细胞趋化蛋白-1与肾功能损伤的相关性研究  

Correlation between serum IL-23,UA,MCP-1 and renal function injury in elderly patients with hyperuricemia

作　　者：王丽媛[1] 张瑞芳 王向托[1] 王雅霄 Liyuan Wang;Ruifang Zhang;Xiangtuo Wang;Yaxiao Wang(Harrison International Peace Hospital,Hengshui 053000,Hebei Province,China)

机构地区：[1]哈励逊国际和平医院,衡水053000

出　　处：《中华肾病研究电子杂志》2023年第3期145-149,共5页Chinese Journal of Kidney Disease Investigation（Electronic Edition）

摘　　要：目的探讨老年高尿酸血症(HUA)患者白细胞介素-23(IL-23)、尿酸(UA)、单核细胞趋化蛋白-1(MCP-1)与肾功能损伤的相关性。方法选取2020年3月至2021年10月我院老年HUA患者112例。收集患者住院期间的临床资料及IL-23、MCP-1水平等实验室指标。通过Logistic多因素回归分析血清指标与肾功能损伤的关联性,采用Spearman相关系数模型分析血清指标水平与不同程度肾功能损伤的关系。通过受试者工作特征(ROC)曲线评价血清指标预测肾功能损伤的价值。结果与肾功能正常患者相比,肾功能损伤患者的病程更长,合并高血压比例更高,血清的IL-23、UA、MCP-1水平增高,GFR减低(P<0.05)。校正后的血清IL-23、UA、MCP-1水平与肾功能损伤的发生存在关联性(P<0.05)。血清IL-23、UA、MCP-1水平与肾功能损伤的程度亦呈正相关(P<0.05),重度肾功能损伤患者的血清IL-23、UA、MCP-1水平最高(P<0.05)。血清IL-23、UA、MCP-1联合预测肾功能损伤的曲线下面积(AUC)为0.892,大于各单独指标。结论老年HUA患者的血清IL-23、UA、MCP-1水平与肾功能损伤的发生以及损伤程度均呈正相关,3个指标联合对老年HUA患者肾功能损伤的预测价值更大。Objective To explore the correlation between renal function damage and interleukin-23(IL-23),uric acid(UA),monocyte chemoattractant protein-1(MCP-1)in elderly patients with hyperuricemia(HUA).Methods A total of 112 elderly HUA patients in our hospital from March 2020 to October 2021 were selected.The clinical and laboratory indicators including IL-23 and MCP-1 were collected.Logistic multivariate regression model was used to analyze the correlation between serum indicators and occurrence of renal function damage in the patients.Spearman correlation coefficient model was used to analyze the relationship between levels of serum indicators and the degree of renal function damage.And receiver operating characteristic(ROC)curve was used to evaluate the value of serum indicators in predicting renal function damage in the patients.Results Compared with patients with normal renal function,the patients with renal function damage showed longer courses of disease,higher proportions of complicated hypertension,higher levels of serum IL-23,UA,and MCP-1,but lower GFR(P<0.05).After adjustment,it was found that there is a correlation between the occurrence of renal function damage and the levels of serum IL-23,UA,and MCP-1(P<0.05).The degree of the renal function damage was also positively correlated with the levels of serum IL-23,UA,and MCP-1(P<0.05),and patients with severe renal function damage had the highest levels of serum IL-23,UA,and MCP-1(P<0.05).The area under the curve(AUC)of the combined serum IL-23,UA,and MCP-1 for prediction of renal function damage was 0.892,which was greater than each of the indicator alone.Conclusion In the elderly patients with HUA,both the occurrence and severity of the renal function damage were positively correlated with the serum levels of IL-23,UA,and MCP-1.The combination of these three indicators may have more value for prediction of the renal function damage in the elderly patients with HUA.

关 键 词：高尿酸血症 肾功能损伤 白细胞介素-23 单核细胞趋化蛋白-1 

分 类 号：R589.7[医药卫生—内分泌]