Organocatalytic atroposelective construction of axially chiral nonsymmetric biaryltriols and their applications in asymmetric synthesis and heavy metal ion detection  

作　　者：Shiqi Jia Wenling Qin Pengfei Wang Hailong Yan 

机构地区：[1]Chongqing Key Laboratory of Natural Product Synthesis and Drug Research,School of Pharmaceutical Sciences,Chongqing 401331,P.R.China

出　　处：《Organic Chemistry Frontiers》2022年第4期923-928,共6页有机化学前沿（英文）

基　　金：This study was supported by the Chongqing Science and Technology Commission(Project No.2020CDJQY-Z002);the Scientific Research Foundation of China(Grant No:21922101,22001025,21901026).

摘　　要：An organocatalytic methodology toward the atroposelective construction of axially chiral nonsymmetric biaryltriols has been successfully developed.A quinine-derived thiourea-catalyzed intramolecular reaction using VQM(vinylidene ortho-quinone methides)intermediates enabled efficient access to a class of axially chiral nonsymmetric biaryltriols with up to 98%yield and 99%ee.

关 键 词：CHIRAL SYMMETRIC AXIAL 

分 类 号：O62[理学—有机化学]