Access to enantioenriched molecules with diverse fluorinated tetrasubstituted stereocenters using hydroxy as a kinetic resolution auxiliary group  

作　　者：Syeda Tazeen Zehra Shouang Lan Hao Zhang Jinggong Liu Shuang Yang Xinqiang Fang 

机构地区：[1]State Key Laboratory of Structural Chemistry,and Key Laboratory of Coal to Ethylene Glycol and Its Related Technology,Center for Excellence in Molecular Synthesis,Fujian Institute of Research on the Structure of Matter,University of Chinese Academy of Sciences,Fuzhou 350100,China [2]Orthopedics Department,Guangdong Provincial Hospital of Traditional Chinese Medicine,The Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510120,China

出　　处：《Organic Chemistry Frontiers》2022年第4期1040-1047,共8页有机化学前沿（英文）

基　　金：Financial support was provided by the NSFC(22071242 and 21871260);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB20000000);Fujian Natural Science Foundation(2018J05035);the Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences.

摘　　要：Developing a general method affording optically pure fully substituted carbon molecules bearing various fluorinated groups is highly important but very challenging.Here we show that using secondary OH as a kinetic resolution auxiliary group,a series of previously unavailable fluorinated fully substituted carbon molecules can be obtained with excellent enantioselectivities,thus providing an alternative complementary method that provides solutions to the limitations confronted by the known methods.

关 键 词：SUBSTITUTED AUXILIARY KINETIC 

分 类 号：O62[理学—有机化学]