基于功能代谢学分析血液环境异常情况下血小板变化及中医药治疗现状  

Analysis of platelet changes in abnormal blood environment and current status of traditional Chinese medicine treatment based on functional metabolism

作　　者：曹策 李玲美 王紫艳 王奥奥 李磊[2] 刘建勋 CAO Ce;LI Ling-mei;WANG Zi-yan;WANG Ao-ao;LI Lei;LIU Jian-xun(Institute of Traditional Chinese Medicine Sciences,Guangdong Pharmaceutical University,Guangzhou 510006,China;Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing Key Laboratory of Chinese Materia Pharmacology,National Clinical Research Center of Traditional Chinese Medicine for Cardiovascular Diseases,Beijing 100091,China)

机构地区：[1]广东药科大学中医药研究院,广州510006 [2]中国中医科学院西苑医院,中药药理北京市重点实验室,国家中医心血管疾病临床医学研究中心,北京100091

出　　处：《中华中医药杂志》2023年第6期2728-2733,共6页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金重点项目(No.82030124)。

摘　　要：血液循环系统环境易受内外因素影响,引发缺氧、缺血或炎症等异常情况,导致血液循环障碍。血小板是由骨髓中巨核细胞细胞质脱落而成,在维持血管完整性和调节止血方面具有关键作用,是血液系统中的重要组成。血小板形态功能的正常是其进行代谢的基础,而正常的代谢是维持形态功能的必然要求,两者相辅相成。血液环境的改变会导致血小板的功能障碍和代谢紊乱,中医药对于血小板功能和代谢的异常变化均具有显著治疗作用,通过抑制血小板活化和聚集、降低血小板黏附性和影响血小板释放等途径,使异常状态的血小板回归正常,从而减轻患者症状、优化治疗效果和提高生活质量。文章以功能学和代谢学为切入点分析血液环境异常情况下血小板变化的机制,整理和阐述中医药治疗研究现状,以期为血小板研究和中医药抗血小板治疗提供理论基础和参考依据。The circulatory system environment is susceptible to internal and external factors that trigger abnormalities such as hypoxia,ischemia,or inflammation,resulting in impaired blood circulation.Platelets are shed from the cytoplasm of megakaryocytes in the bone marrow and play a key role in maintaining vascular integrity and regulating hemostasis,and are an important component of the blood system.Normal morphological function of platelets is the basis for metabolism,and normal metabolism is an inevitable requirement to maintain morphological function,and the two complement each other.Changes in the blood environment can lead to platelet dysfunction and metabolic disorders.Traditional Chinese medicine(TCM)has a significant therapeutic effect on abnormal changes in platelet function and metabolism.By inhibiting platelet activation and aggregation,reducing platelet adhesion and affecting platelet release,it can make abnormal platelets return to normal,thereby reducing patient symptoms,optimizing treatment effects,and improving quality of life.This paper analyzes the mechanism of changes of platelets in abnormal blood environment based on functional science and metabolism,and collates and elaborates the current status of TCM treatment research,so as to provide a theoretical basis and reference for platelet research and TCM anti-platelet therapy.

关 键 词：血液系统 血小板 中医药 有效成分 功能代谢学 抗血小板机制 

分 类 号：R259[医药卫生—中西医结合]