Catalytic asymmetric oxidative sulfenylation of β-ketocarbonyls using a chiral primary amine  

作　　者：Qi Zhang Mingying Shi Xueling Mi Sanzhong Luo 

机构地区：[1]Key Laboratory of Molecular Recognition and Function,Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190,China [2]School of Chemical Science,University of Chinese Academy of Sciences,Beijing 100490,China [3]College of Chemistry,Beijing Normal University,Beijing 100875,China [4]Center of Basic Molecular Science,Department of Chemistry,Tsinghua University,Beijing,100084,China

出　　处：《Organic Chemistry Frontiers》2022年第5期1276-1281,共6页有机化学前沿（英文）

基　　金：We thank the National Natural Science Foundation of China(21672217,21861132003 and 22031006);the Tsinghua University Initiative Scientific Research Program for financial support.

摘　　要：Enantioselective oxidative construction of a C(sp^(3))–S bond has been achieved using a chiral primary amine catalyst in the presence of tert-butyl hydroperoxide and a catalytic amount of tetrabutylammonium iodide.The distinctive feature of the current reaction is coupling with nucleophilic sulfur reactants under oxidative conditions.This protocol provides facile access to chiral thioethers bearing S-containing quaternary stereocenters with good chemo-and enantiocontrol.

关 键 词：OXIDATIVE CHIRAL ASYMMETRIC 

分 类 号：O62[理学—有机化学]