A visible light-mediated three-component strategy based on the ring-opening of cyclic ethers with aryldiazoacetates and nucleophiles  

作　　者：Mateus L.Stivanin Rafael D.C.Gallo Joao Paulo M.Spadeto Rodrigo A.Cormanich Igor D.Jurberg 

机构地区：[1]State University of Campinas,Institute of Chemistry,Rua Monteiro Lobato 270,13083-862 Campinas,SP,Brazil

出　　处：《Organic Chemistry Frontiers》2022年第5期1321-1326,共6页有机化学前沿（英文）

基　　金：Financial support is greatly appreciated from CNPq for a PhD fellowship to M.L.S.(142474/2018-5);FAPESP for a post-doc-toral fellowship to R.D.C.G.(2020/00144-6);a Young Researcher Grant to R.A.C(2018/03910-1);a PhD fellowship to J.P.M.S.(2020/06536-3);a Regular Research Grant to I.D.J.(2019/01235-8);The authors also thank FAEPEX for a fellowship to R.A.C.(2466/20).

摘　　要：A blue light-promoted reaction between aryldiazoacetates and different nucleophiles has been developed in the presence of THF(and other cyclic ethers)as the solvent,allowing the incorporation of these three elements into a single product.Formally,this transformation represents an O–H insertion strategy of more complex alcohols into aryldiazoesters,without the need of pre-assembling them.The method is mild and efficient and proceeds in the absence of metals,generally at room temperature.

关 键 词：temperature VISIBLE LIGHT 

分 类 号：O62[理学—有机化学]