Highly diastereoselective cascade dearomatization of 3-(2-isocyanoethyl)indoles with nitrile imines: a facile access to unexpected polycyclic indolines  

作　　者：Xiaohu Zhao Yuqiao Zhou Bao-Lin Li Guangxi Du Zhipeng Yu 

机构地区：[1]Key Laboratory of Green Chemistry&Technology,Ministry of Education,College of Chemistry,Sichuan University,Chengdu 610064,China

出　　处：《Organic Chemistry Frontiers》2022年第5期1336-1342,共7页有机化学前沿（英文）

基　　金：The financial support was provided by the National Natural Science Foundation of China(no.22001181 and 22077090);the Sichuan Science and Technology Program(2021YJ0407).

摘　　要：A highly efficient dearomatization of 3-(2-isocyanoethyl)indoles with in situ generated nitrile imines has been developed through a nucleophilic/Friedel–Crafts/aza-Mannich type cascade and 1,3-dipolar cyclo-addition reaction under catalyst-free and mild reaction conditions.This strategy offers a novel and con-venient route to the rapid assembly of a wide range of unprecedented polycyclic indoline scaffolds in moderate to excellent yields and diastereoselectivities.

关 键 词：conditions NITRILE indole 

分 类 号：O62[理学—有机化学]