持留菌的临床相关性及防治研究进展  

Advances in clinical relevance and treatment strategies of bacterial persisters

作　　者：冯佳妮 李玮玮 朱伟伟 薛云新[1] 王岱[1] 赵西林[1] Feng Jia-ni;Li Wei-wei;Zhu Wei-wei;Xue Yun-xin;Wang Dai;Zhao Xi-lin(State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,School of Public Health,Xiamen University,Xiamen 361102)

机构地区：[1]厦门大学公共卫生学院分子疫苗学和分子诊断学国家重点实验室,厦门361102

出　　处：《中国抗生素杂志》2023年第5期499-506,共8页Chinese Journal of Antibiotics

基　　金：国家自然科学基金(No.81971905和No.82172316)。

摘　　要：持留菌(persisters)指的是细菌群体中的一个小亚群,它们可以在致死浓度的抗生素应激下进入休眠状态,躲避抗生素的杀伤,然而这种耐受抗生素的能力并不具备可遗传性,在抗生素压力降低或者去除时持留菌便可正常生长并恢复对抗生素杀菌的敏感性。本文介绍了持留菌的生物学特性及其与慢性感染等临床相关问题的关系,综述了TA模块及SOS反应等促进细菌持留形成的分子机制,总结了现有研究中针对细菌持留可行的防治手段,以期引发临床对持留菌更广泛的关注和警惕,且为持留菌的深入研究与防治提供参考。Persisters refer to a small subgroup of bacterial populations that can enter a dormant state under lethal concentrations of antibiotic stress and evade the killing by antibiotics.However,the ability of persisters to tolerate antibiotic killing is not heritable.Persister bacterial cells can resume normal growth when the antibiotic pressure dissipates and regain sensitivity to antibiotic-mediated killing.In this paper,the biological characteristics of persistent bacteria and their relationship with related clinical issues,such as chronic infection,are introduced.The molecular mechanisms of toxin-antitoxin(TA)modules and SOS responses that promote the formation of bacterial persistence are reviewed.Currently available preventive strategies that are feasible for controlling bacterial persistence are also summarized in order to draw broad attention to and remain vigilance on clinical implications of persistent bacteria.Such work is expected to provide guidance for in-depth research and preventive measures of persistent bacteria.

关 键 词：抗生素 持留菌 慢性感染 生物膜 防治策略 

分 类 号：R9[医药卫生—药学]