生痰二氧化碳嗜纤维菌血流感染及文献复习  

Capnocytophaga sputigena bacteremia:Case report and review of literatures

作　　者：梁良[1] 居阳[2] 黄莹莹[3] 葛春悦 翁剑真 朱愿超[1] 石鑫 Liang Liang;Ju Yang;Huang Ying-ying;Ge Chun-yue;Weng Jian-zhen;Zhu Yuan Chao;Shi Xin(Department of Pharmaceutical Science,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Science,Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application,Beijing Hospital,Beijing 100730;Department of Pulmonary and Critical Care Medicine,Beijing Hospital,National Center of Gerontology,Institute of Geriatrics Medicine,Chinese Academy of Medical Sciences,Beijing 100730;Department of Oncology,Beijing Hospital,National Center of Gerontology,Institute of Geriatrics Medicine,Chinese Academy of Medical Sciences,Beijing 100730;Department of Clinical Laboratory,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing 100730)

机构地区：[1]北京医院药学部,国家老年医学中心,中国医学科学院老年医学研究院,北京市药物临床风险与个体化应用评价重点实验室,北京100730 [2]北京医院呼吸与危重症医学科,国家老年医学中心,中国医学科学院老年医学研究院,北京100730 [3]北京医院肿瘤科,国家老年医学中心,中国医学科学院老年医学研究院,北京100730 [4]北京医院检验科,国家老年医学中心,中国医学科学院老年医学研究院,北京100730

出　　处：《中国抗生素杂志》2023年第5期595-600,I0001,共7页Chinese Journal of Antibiotics

基　　金：国家重点研发计划(No.2020YFC2008304)。

摘　　要：目的总结分析生痰二氧化碳嗜纤维菌血流感染患者的临床特点及易感因素,提高临床诊治水平。方法回顾性分析北京医院收治的1例生痰二氧化碳嗜纤维菌血流感染患者的临床资料,并进行相关文献复习。中文以“生痰二氧化碳嗜纤维菌”为检索词,英文以“Capnocytophaga sputigena”为检索词,检索PubMed/Medline、Embase、中国期刊网数据库(CNKI)、万方数据库(Wanfang)、维普网(VIP)、中国生物医学文献数据库(CBM)等数据库,纳入文献范围为2021年10月10日前发表的所有中文及英文文献。结果患者男,22岁,左侧颌面部肿瘤3程化疗后,第4程化疗前出现发热寒颤,白细胞及中性粒细胞升高,血培养需氧瓶及厌氧瓶均为生痰二氧化碳嗜纤维菌。文献检索共检索国内外病历报道37例,其中34例报道了明确的治疗方案。结合本例患者,共35例,其中女性18例,男性16例,未知性别1例,年龄介于0~94岁。感染部位方面,20例患者为血流感染,其中4例同时合并其它部位的感染。除1例患者流产后没有给予任何药物治疗外,34例患者接受了基于β-内酰胺类药物的治疗方案,有5例患者同时接受了外科手段干预。在随访过程中,5例患者死亡。结论生痰二氧化碳纤维菌引起的感染临床少见,美国临床和实验室标准化协会(CLSI)并未对生痰二氧化碳嗜纤维菌推荐药敏试验方法及折点范围,临床中多经验性使用基于β-内酰胺类药物的治疗方案。疾病预后较好。Objective To analyze the clinical characteristic and risk factor of Capnocytophaga sputigena bacteremia.Methods A patient with Capnocytophaga sputigena bacteremia was review.We conducted a literature search using the database of PubMed/Medline,Embase,CNKI,Wanfang,VIP,and CBM before October 10th,2021.Results A 22-year-old male patient received three cycles chemo-therapy because of left maxillofacial tumor.Before the forth cycle chemotherapy,he had a fever with chills and elevated white blood cells.Both the aerobic and anaerobic were Capnocytophaga sputigena.A total of 37 cases were reported,34 of which listed therapy regimen.35 cases were included.18 were female,16 were male,and one unknow.20 were bacteremia,seven were pulmonary infection,three were infection of soft tissue and bone,one was ocular infection,and one was umbilical corditis.34 patients except one received beta-lactam-based therapy regimen.Five patients received drainage or surgery.Five patients died during follow-up,three died from infection,two died from other disease.Conclusion Capnocytophaga sputigena infection was a rare disease.There was no antimicrobial susceptibility testing and breakpoint for Capnocytophaga sputigena by Clinical and Laboratory Standards Institute(CLSI).Empirical treatment was beta-lactam-based therapy regimen.

关 键 词：生痰二氧化碳嗜纤维菌 血流感染 

分 类 号：R978.1[医药卫生—药品]