度普利尤单抗成功治疗嗜酸性粒细胞增多综合征一例  

A case of hypereosinophilic syndrome successfully treated with dupilumab

作　　者：丁高中 李姗姗[2] 孙澜[1] 魏云[1] DING Gaozhong;LI Shanshan;SUN Lan;WEI Yun(Department of Dermatology,the Affiliated Suzhou Hospital of Nanjing Medical University,East District of Suzhou Municipal Hospital,Suzhou 215001,China;Department of Dermatology,the Fifth People's Hospital of Suzhou,Suzhou 215001,China)

机构地区：[1]南京医科大学附属苏州医院苏州市立医院东区皮肤科,江苏苏州215001 [2]苏州大学附属传染病医院,苏州市第五人民医院皮肤科,江苏苏州215001

出　　处：《中国麻风皮肤病杂志》2023年第8期576-579,共4页China Journal of Leprosy and Skin Diseases

基　　金：苏州市“科教兴卫”青年科技项目(编号:KJXW2021052);南京医科大学姑苏学院科研项目(编号:GSKY20210230)。

摘　　要：目前国外有度普利尤单抗治疗嗜酸性粒细胞增多综合征报道,国内尚无相关报道。本文首报度普利尤单抗治疗嗜酸性粒细胞增多综合征1例,患者首次注射剂量600 mg,1周后予以300 mg皮下注射,之后每2周皮下注射300 mg,患者治疗3周后,瘙痒明显缓解,7周后皮损基本消退。首剂治疗后第3天出现下肢丹毒,经抗感染治疗好转。Treatment of hypereosinophilic syndrome with dupriulizumab has been reported abroad,but not in China.Herein,we report a case of dupriulizumab in the treatment of hypereosinophilic syndrome successfully.The patient received subcutaneous injection of dupilumab at an initial dose of 600 mg,300 mg after 1 week,then once every 2 weeks with a dose of 300 mg.After 3 weeks of treatment,the pruritus was significantly relieved,and the skin lesions basically subsided after 7 weeks.Erysipelas appeared on the 3rd day after the first dose of treatment,which was improved by anti-infection.

关 键 词：嗜酸性粒细胞增多综合征 度普利尤单抗 丹毒 

分 类 号：R557.5[医药卫生—血液循环系统疾病]