铁死亡在骨关节炎中的作用机制及其中医药干预研究进展  

Mechanism of ferroptosis in osteoarthritis and its traditional Chinese medicine interventions

作　　者：高振罡 章晓云[1] 蒋文[1] Gao Zhengang;Zhang Xiaoyun;Jiang Wen(Ruikang Hospital,Guangxi University of Chinese Medicine,Nanning 530000,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]广西中医药大学附属瑞康医院,广西壮族自治区南宁市530000

出　　处：《中国组织工程研究》2024年第14期2242-2247,共6页Chinese Journal of Tissue Engineering Research

基　　金：基金资助:国家自然科学基金资助项目(81960803);广西自然科学基金青年基金(2020GXNSFBA159053),项目负责人:章晓云;广西中医药适宜技术开发与推广项目(GZSY22-36),项目负责人:章晓云;黄有荣桂派中医大师培养项目(桂中医药科教发[2022]6号);广西中医药大学桂派中医药传承创新团队(2022A004),项目参与人:章晓云;广西中医药大学青年创新研究团队项目(2021TD001),项目负责人:章晓云。

摘　　要：背景:有研究发现,软骨细胞铁死亡可作为重要的发病机制诱导骨关节炎的发生与发展。随着祖国医学的不断发展,有学者发现某些中药单体、中药复方等可通过多种作用机制抑制软骨细胞发生铁死亡,最终起到治疗骨关节炎的作用。目的:探讨铁死亡与骨关节炎的关系及中医药干预铁死亡治疗骨关节炎的作用机制,以期为骨关节炎的治疗及预防提供新的思路。方法:以“铁死亡,骨关节炎,软骨细胞,脂质代谢,中医药,活性氧,谷胱甘肽过氧化物酶”为中文检索词,以“osteoarthritis,ferroptosis,chondrocytes,lipid metabolism,traditional Chinese medicine,ROS,GPX4”为英文检索词,检索中国知网、PubMed、万方、维普等数据库,筛选各数据库建库至2022年铁死亡与骨关节炎及其中医药干预研究的相关文章,并进行系统的整理分析。结果与结论:①细胞内铁超载会引发脂质过氧化反应,造成活性氧积累,最终导致铁死亡的发生,而铁过量会加速软骨细胞凋亡,影响软骨细胞的稳态,进而诱导骨关节炎的发生。②氨基酸代谢异常时,谷氨酸与胱氨酸交换失衡,导致谷氨酸在细胞外积聚,进而导致谷胱甘肽被耗尽,间接抑制了铁死亡相关因子的功能,对铁死亡起到促进作用。③细胞脂质代谢异常时,细胞膜的重要组成部分不饱和脂肪酸失去双烯丙基氢原子,导致细胞被破坏诱发铁死亡,而脂质代谢与骨关节炎的发生发展密切相关。④中医药可以通过干预诱导铁死亡发生的相关机制对骨关节炎起到防治作用。目前对铁死亡的研究仍不成熟,继续深入研究其作用机制,有望为临床治疗骨关节炎开辟新途径。BACKGROUND:Studies have found that chondrocyte ferroptosis can be used as an important pathogenesis to induce the occurrence and development of osteoarthritis.With the continuous development of Chinese medicine,some scholars have found that some traditional Chinese medicine monomers and traditional Chinese medicine compounds can inhibit chondrocyte ferroptosis through various mechanisms of action,and finally play a role in the treatment of osteoarthritis.OBJECTIVE:To explore the relationship between ferroptosis and osteoarthritis and the mechanism by which traditional Chinese medicine deals with ferroptosis in the treatment of osteoarthritis,in order to provide new ideas for the treatment and prevention of osteoarthritis.METHODS:With“osteoarthritis,ferroptosis,chondrocytes,lipid metabolism,traditional Chinese medicine,ROS,GPX 4”as the English and Chinese search terms,CNKI,PubMed,WanFang,and VIP databases were searched for relevant articles regarding the relationship between ferroptosis and osteoarthritis and its traditional Chinese medicine intervention until 2022.Then,a systematic analysis was conducted.RESULTS AND CONCLUSION:Intracellular iron overload will cause lipid peroxidation,resulting in the accumulation of reactive oxygen species and eventually the occurrence of ferroptosis,while excessive iron will accelerate the apoptosis of chondrocytes and affect chondrocyte homeostasis,thereby inducing the development of osteoarthritis.When amino acid metabolism is abnormal,an imbalance in glutamate and cystine exchange causes the accumulation of glutamate outside the cells,and high extracellular concentration of glutamate will cause the depletion of glutathione,indirectly inhibiting the function of ferroptosis-related factors,and contributing to ferroptosis.When cellular lipid metabolism is abnormal,unsaturated fatty acids,an important component of the cell membrane,lose their diallyl hydrogen atoms,leading to the destruction of cells to induce ferroptosis,while lipid metabolism is closely involved in the prog

关 键 词：骨关节炎 铁死亡 软骨细胞 脂质代谢 中医药 研究进展 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R242