长链非编码RNA与牙周炎  

Long non-coding RNA and periodontitis

作　　者：佟彤 刘春艳[2] 刘冰[3] 赵菲 Tong Tong;Liu Chunyan;Liu Bing;Zhao Fei(School/Hospital of Stomatology,Hebei Medical University,Hebei Province Key Laboratory of Stomatology,Hebei Province Clinical Medical Research Center of Oral Diseases,Shijiazhuang 050017,Hebei Province,China;Department of Orthodontics,Hebei Medical University,Shijiazhuang 050017,Hebei Province,China;Department of Periodontics I,School of Stomatology,Hebei Medical University,Shijiazhuang 050017,Hebei Province,China)

机构地区：[1]河北医科大学口腔医学院•口腔医院,河北省口腔医学重点实验室,河北省口腔疾病临床医学研究中心,河北省石家庄市050017 [2]河北医科大学口腔医学院正畸科,河北省石家庄市050017 [3]河北医科大学口腔医学院牙周一科,河北省石家庄市050017

出　　处：《中国组织工程研究》2024年第14期2267-2273,共7页Chinese Journal of Tissue Engineering Research

基　　金：2021年政府资助省级医学优秀人才项目(361029),项目负责人:刘春艳;2022年河北省医学科学研究课题计划(20221454),项目负责人:赵菲;2019年河北省政府资助临床医学优秀人才培养和基础课题研究项目[361029(MXZB00271)],项目负责人:刘冰。

摘　　要：背景:近年来,大量研究显示长链非编码RNA(long non-coding RNA,lnc RNA)在牙周炎的发病过程有重要作用,包括免疫反应过程及细胞(牙周膜干细胞、破骨细胞)的生物活性和功能,人们试图通过调控lnc RNA表达水平来实现对牙周炎症的调控及牙周组织的再生。目的:就lnc RNA在牙周炎中的研究进展进行综述,以期望更好地推进lnc RNA在牙周炎的研究。方法:第一作者检索Pub Med、中国知网等数据库建库到2023年3月发表的相关文献,以“长链非编码RNA,lnc RNA,牙周炎,牙周,免疫,炎症,牙周膜干细胞,破骨细胞,成骨分化,骨吸收,骨形成,复发,缺氧,氧化应激,静态机械应变”为中文检索词;“lnc RNA,periodontitis,periodontal,immunity,inflammation,periodontalmembranestemcells,osteoclasts,osteogenicdifferentiation,bone resorption,bone formation,recurrence,hypoxia,oxidative stress,static mechanical strain”为英文检索词,阅读每篇文献的文题、摘要进行初筛,最终筛选出87篇文献进行归纳分析。结果与结论:(1)牙周致病菌刺激机体导致免疫效应失衡引发炎症反应造成牙周组织的破坏,lnc RNA参与其调控机制。(2)lnc RNA对炎性环境的牙周膜细胞主要参与了促炎的调控,对于破骨细胞分化的影响,通过ce RNA机制进行调控,为探究牙周炎发病机制提供了新的线索。对于B细胞及巨噬细胞,lnc RNA在牙周炎中可调控其亚群的浸润、细胞活性和功能发挥。(3)lnc RNA参与牙周炎相关免疫反应主要在Toll样受体与NOD样受体两种模式识别受体与核因子κB途径这一信号通路发挥作用。(4)探究lnc RNA是否可作为牙周炎生物学标志在牙周炎的诊断及预后复发问题上有很大价值。(5)已有动物实验证实了可以通过调控lnc RNA的表达水平来逆转lnc RNA在牙周炎的作用从而起到抗炎作用,其对牙周炎的免疫治疗研究有很大价值。(6)Lnc RNA对于牙周膜干细胞的调控主要通过内源性竞BACKGROUND:In recent years,numerous studies have shown that long non-coding RNAs(lncRNAs)have an important role in the pathogenesis of periodontitis,including the immune response process and the biological activity and function of cells(periodontal stem cells and osteoblasts).Researchers attempt to regulate periodontal inflammation and periodontal regeneration by regulating lncRNA expression levels.OBJECTIVE:To review the progress of research on lncRNAs in periodontitis,thereby advancing the research of lncRNAs in periodontitis.METHODS:The first author searched PubMed,China National Knowledge Infrastructure(CNKI),Web of Science database,and WanFang Database for relevant literature published up to March 2023.“Long non-coding RNA,lncRNA,periodontitis,periodontium,immunity,inflammation,periodontal ligament stem cells,osteoclasts,osteogenic differentiation,bone resorption,bone formation,recurrence,hypoxia,oxidative stress,static mechanical strain”were used as the Chinese search terms.“lncRNA,periodontitis,periodontal,immunity,inflammation,periodontal membrane stem cells,osteoclasts,osteogenic differentiation,bone resorption,bone formation,recurrence,hypoxia,oxidative stress,static mechanical strain”were used as the English search terms.The title and abstract of each paper were read for initial screening,and 87 papers were finally selected for inductive analysis.RESULTS AND CONCLUSION:Periodontal pathogens stimulate the body,leading to immune imbalance that triggers inflammatory response and destroy periodontal tissue,and lncRNAs are involved in its regulatory mechanism.LncRNAs are involved in the pro-inflammatory regulation of periodontal ligament cells in an inflammatory environment,and their effects on osteoclast differentiation are regulated through ceRNA mechanism,which provides new clues for exploring the pathogenesis of periodontitis.For B cells and macrophages,lncRNAs can regulate the infiltration,cell activity and function of their subsets in periodontitis.LncRNAs participate in the immune response re

关 键 词：长链非编码RNA 牙周炎 牙周膜干细胞 破骨细胞 免疫 牙周再生 发病机制 应用 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R781.42