天然产物8-异戊烯基-7,3′,4′-三羟基黄烷酮的全合成研究  

Total Synthesis of 8-Isoprenyl-7,3′,4′-trihydroxy Flavanone

作　　者：赵艳敏[1] 李红俊 ZHAO Yanmin;LI Hongjun(Department of Chemical and Biological Engineering,Yinchuan University of Energy,Yinchuan 750105,China;Ningxia Academy of.Metrology and Quality Inspection,Yinchuan 750411,China)

机构地区：[1]银川能源学院化学与生物工程学院,宁夏银川750105 [2]宁夏计量质量检验检测研究院,宁夏银川750411

出　　处：《合成化学》2023年第7期550-553,共4页Chinese Journal of Synthetic Chemistry

基　　金：宁夏自然科学基金资助项目(2020AAC03275);宁夏高等学校科学研究项目(NYG2022135)。

摘　　要：8-异戊烯基-7,3′,4′-三羟基黄烷酮是一种新分离的天然产物,但在植物中含量低且分离困难,因此以廉价的2,4-二羟基苯乙酮和3,4-二羟基苯甲醛为原料,经过C-异戊烯基化、酚羟基保护、羟醛缩合、环化和去保护基等步骤,以21%的总收率第一次全合成了天然产物8-异戊烯基-7,3′,4′-三羟基黄烷酮。所有新化合物的结构都经过^(1)H NMR、IR和HR-MS确认。8-isopentenyl-7,3′,4′-trihydroxyflavanone is a new natural product,but its content in plants is low and its separation is difficult,so we synthesized the natural product was achieved through C-prenylation,protection of phenolic hydroxyl group,aldol condensation,cyclization and deprotection starting from cheap 2,4-dihydroxyacetophenone and 2,4-dihydroxybenzaldehy-de,with total yield 21%.All structures of new compounds were confirmed by IR,^(1)H NMR and MS.

关 键 词：天然产物 黄烷酮 异戊烯基黄烷酮 异戊烯基化 全合成 

分 类 号：O625.1[理学—有机化学]