中青年女性自身免疫性甲状腺炎与幽门螺杆菌感染及菌株分型的相关性研究  

A Correlation Study of Helicobacter Pylori and Autoimmune Thyroiditis Among Young and Middle Aged Female Patients

作　　者：陈燕燕 陈刚 谷珊珊 王金娥 包贺菊 马昆 CHEN Yanyan;CHEN Gang;GU Shanshan;WANG Jin’e;BAO Heju;MA Kun(Department of Nuclear Medicine,General Hospital of Civil Aviation,Beijing 100123,China)

机构地区：[1]民航总医院核医学科,北京100123

出　　处：《标记免疫分析与临床》2023年第4期564-567,608,共5页Labeled Immunoassays and Clinical Medicine

摘　　要：目的 探讨中青年女性幽门螺杆菌(helicobacter pylori, Hp)感染及菌株分型与自身免疫性甲状腺炎(autoimmune thyroiditis, AIT)的关系。方法 选取2020年1月至2021年12月在我院内分泌科就诊的自身免疫性甲状腺炎中青年女性患者120例为AIT组,相同年龄段健康女性120例为对照组,采用免疫印迹法检测血清Hp UreB抗体及CagA抗体,采用化学发光法检测TPOAb及TGAb定量值,比较两组间UreB抗体及CagA抗体阳性率有无差异。将AIT组及对照组分为无Hp感染组(UreB-)、非产毒Hp感染组(UreB+,CagA-)及产毒Hp感染组(UreB+,CagA+),比较两亚组间差异;同时比较AIT组UreB抗体阳性组与阴性组、CagA抗体阳性组与阴性组间TPOAb及TGAb定量值有无差异。结果AIT组Hp感染率明显高于对照组(68.3%vs 48.3%,P=0.003),且AIT组中CagA阳性率明显高于对照组(47.5%vs 32.5%,P=0.025);AIT组无Hp感染组例数明显低于对照组(P=0.004),且产毒Hp感染组患者比例明显高于对照组(P=0.025);AIT组中UreB抗体阳性组与阴性组TPOAb及TGAb定量值差异无统计学意义(P=0.19及P=0.678),CagA抗体阳性组与阴性组间两者定量值差异亦无统计学意义(P=0.301及P=0.809)。结论 幽门螺杆菌感染及毒力菌株CagA阳性与中青年女性自身免疫性甲状腺炎相关,但是与TPOAb及TGAb定量值无明显相关性。Objective To investigate the relationship between Helicobacter pylori(Hp)infection and Autoimmune thyroiditis(AIT)in young and middle-aged female patients.Methods A total of 120 young and middle-aged female patients with AIT from the Endocrine Department of our hospital from January,2020 to December,2021 were selected as the experimental group,while 120 healthy women with the same age were selected as the control group.Serum Hp UreB and CagA were detected by immunoblotting method,and the quantitative values of TPOAb and TGAb were detected by chemiluminescence method.The positive rates of UreB and CagA were compared between the two groups.The experimental group and the control group were further divided into the non-Hp infection group(UreB-),non-toxigenic Hp infection group(UreB+,CagA-)and toxigenic Hp infection group(UreB+,CagA+).The differences in subgroups between the two groups were evaluated.The quantitative values of TPOAb and TGAb between UreB positive group and UreB negative group,CagA positive group and CagA negative group were compared.Results The infection rate of Hp in the experimental group was significantly higher than that in the control group(68.3%vs.48.3%,P=0.003),and the positive rate of CagA in the experimental group was significantly higher than that in the control group(47.5%vs.32.5%,P=0.025).The number of cases in the group without Hp infection in the test group was significantly lower than that in the control group(P=0.004),and the proportion of patients in the toxigenic Hp infection group was significantly higher than that in the control group(P=0.025).There was no significant difference in the quantitative values of TPOAb and TGAb between UreB positive group and UreB negative group(P=0.19 and P=0.678),and there was no significant difference between CagA positive group and CagA negative group(P=0.301and P=0.809).Conclusion Helicobacter pylori infection and positive virulent strain CagA are closely related to AIT in young and middle-aged female patients,while there is no significant correlat

关 键 词：幽门螺杆菌 自身免疫性甲状腺炎 CAGA抗体 

分 类 号：R581.4[医药卫生—内分泌]