脑反射联合普罗布考疗法对颈动脉斑块稳定度、血清GDF15、PON1指标水平的影响及相关性分析  

A Study of Effects of Cerebral Reflex Combined with Probucol Therapy on Carotid Plaque Stability, Serum GDF15 and PON1 Levels and Related Correlation Analysis

作　　者：常玮鑫 孙丽坤 赵凤依 CHANG Weixin;SUN Likun;ZHAO Fengyi(Zhangjiakou Second Hospital,Zhangjiakou 075000,China)

机构地区：[1]张家口市第二医院,河北张家口075000

出　　处：《标记免疫分析与临床》2023年第4期609-614,共6页Labeled Immunoassays and Clinical Medicine

基　　金：张家口市科技计划自筹经费项目(编号:1921074D)。

摘　　要：目的 探究脑反射联合普罗布考对颈动脉斑块稳定性、血清生长分化因子15(GDF15)、血对氧磷酶1(PON1)的影响及相关性分析。方法 选取2019年6月至2022年6月入我院就诊的具备脑血管缺血表现症状且颈动脉可见斑块形成的患者共214例,依照干预治疗方案的不同将纳入患者分为联合治疗组(n=102)和对照组(n=112)。对照组采用普罗布考药物治疗方式,联合治疗组采用脑反射联合普罗布考疗法,观察两组治疗前后颈动脉状态等指标差异,对比两组治疗前后血清GDF15及PON1指标、血脂指标、神经功能评分(NIHSS)差异,采用Spearman相关系数分析分析患者颈动脉斑块稳定性与血清GDF15及PON1指标相关性。结果 治疗后联合治疗组斑块稳定患者例数明显高于对照组;治疗后两组IMT值、斑块数量及面积较治疗前均明显降低,且联合治疗组各指标水平较对照组显著降低(P<0.001);治疗后两组血清GDF15指标较治疗前均明显降低,且联合治疗组明显低于对照组,两组血清PON1较治疗前均明显升高,且联合治疗组明显高于对照组(均P<0.05);治疗后两组三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)指标水平较治疗前均明显降低,且联合治疗组各指标值明显低于对照组(均P<0.05);治疗后两组高密度脂蛋白胆固醇(HDL-C)指标水平较治疗前均明显升高,且联合治疗组指标值明显高于对照组(P<0.05);治疗后两组NIHSS评分结果较治疗前均明显降低,且联合治疗组评分结果明显低于对照组(P<0.05);采用Spearman相关系数分析显示患者颈动脉斑块稳定性与血清GDF15指标呈负相关,与PON1指标呈正相关(均P<0.05)。结论 脑反射联合普罗布考治疗方案对改善患者颈动脉斑块状态、血清GDF15、PON1指标及血脂等具有积极效用,亦可有效减轻患者神经功能缺损程度,值得临床推广应用。此外,本研究发现血清GDF15、PON1指标与缺血性脑血管�Objective To investigate the effects of brain emission combined with probucol on carotid plaque stability,serum growth differentiation factor 15(GDF15)and blood paraoxonase 1(PON1)and its correlation analysis.Methods A total of 214 patients with cerebrovascular ischemia symptoms and visible carotid plaque formation admitted to our hospital from June,2019 to June,2022 were selected and divided into combination treatment group(n=102)and control group(n=112)according to different intervention treatment plans.The control group was treated with probuco,and the combined treatment group was treated with cerebral reflex combined with probuco.The differences of carotid artery status and other indicators between the two groups before and after treatment were evaluated,and the levels of serum GDF15 and PON1 indexes,blood lipid indexes and neurological function score(NIHSS)between the two groups were compared.Spearman correlation coefficient analysis was used to analyze the correlation between carotid plaque stability and serum GDF15 and PON1.Results After treatment,the number of patients with plaque stability in the combined treatment group increased significantly than that in the control group.After treatment,IMT value,plaque number and area in the two groups decreased significantly than before treatment,and the indexes in the combined treatment group decreased significantly than those in the control group(P<0.001).After treatment,the serum GDF15 index in both groups decreased significantly than that before treatment,and that in the combined treatment group decreased significantly than that in the control group.Serum PON1 in both groups increased significantly than that in the combined treatment group(P<0.05).After treatment,the levels of triglyceride(TG),total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-C)in the two groups decreased significantly than those before treatment,and the indexes in the combined treatment group decreased significantly than those in the control group(all P<0.05).After treatment,the

关 键 词：颈动脉斑块 脑反射治疗 普罗布考 颈动脉斑块稳定性 血清生长分化因子15 血对氧磷酶1 

分 类 号：R543.4[医药卫生—心血管疾病]