GnRH-a对子宫内膜异位症患者子宫内膜PDGF、LN表达的影响  

Effect of GnRH-a on the Expression of PDGF and LN in the Endometrium of Patients with Endometriosis

作　　者：白雨昕 魏宏[1] 张东霞 BAI Yu-xin;WEI Hong;ZHANG Dong-xia(The Central Hospital of Jiamusi City,Heilongjiang Jiamusi 154002)

机构地区：[1]佳木斯市中心医院,黑龙江佳木斯154002

出　　处：《深圳中西医结合杂志》2023年第10期11-15,共5页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探讨促性腺激素释放激素激动剂(GnRH-a)对子宫内膜异位症(EM)患者子宫内膜血小板衍生因子(PDGF)、人层粘连蛋白(LN)表达的影响。方法:选取2019年5月至2022年3月佳木斯市中心医院收治的84例EM患者作为研究对象,将患者随机分为对照组和观察组,各42例。对照组给予腹腔镜下手术治疗,观察组在对照组治疗的基础上给予GnRH-a治疗,检测并比较所有患者治疗前后子宫内膜PDGF、LN表达变化情况。结果:观察组患者治疗3个月后的总有效率为97.6%,与对照组的85.7%相比有显著提高,差异具有统计学意义(P<0.05)。治疗后,观察组患者血清黄体生成素(LH)含量明显低于治疗前,与对照组比较也明显更低,差异均具有统计学意义(P<0.05);两组患者治疗前后的血清卵泡刺激素(FSH)含量比较,差异无统计学意义(P>0.05)。治疗后,两组患者的子宫内膜PDGF表达水平明显低于治疗前,LN表达水平与治疗前相比明显增高,差异具有统计学意义(P<0.05),治疗后观察组PDGF、LN表达水平与对照组比较,差异具有统计学意义(P<0.05)。两组患者治疗后的痛经视觉模拟评分法(VAS)评分都显著低于治疗前,且观察组显著低于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后的头晕失眠、情绪波动、乏力、潮热盗汗等不良反应发生率比较,差异无统计学意义(P>0.05)。结论:GnRH-a在EM患者治疗的应用能提高治疗效果,降低患者的痛经程度,也可抑制血清LH的水平,有利于子宫内膜PDGF、LN水平恢复平衡。Objective To investigate the effect of gonadotropin-releasing hormone agonist(GnRH-a)on the expression of endometrial platelet derived growth factor(PDGF)and human laminin(LN)in patients with endometriosis(EM).Methods 84 patients with EM admitted to The Central Hospital of Jiamusi City from May 2019 to March 2022 were selected for the study,and the patients were randomly divided into a control group and an observation group,with 42 cases in each group.The control group was given laparoscopic surgery,and the observation group was given GnRH-a treatment on the basis of the treatment in the control group.The changes of PDGF and LN expression in the endometrium of all patients before and after treatment were detected and compared.Results The total effective rate of patients in the observation group at 3 months after treatment was 97.6%,which was significantly higher compared with 85.7%of the control group,with a statistically significant difference(P<0.05).After treatment,the level of serum luteinizing hormone(LH)in the observation group was significantly lower than that before treatment,and was also significantly lower compared with that of the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference between the level of serum follicle stimulating hormone(FSH)of the two groups before and after treatment(P>0.05).After treatment,the level of endometrial PDGF in both groups was significantly lower than that before treatment,and the level of LN was significantly higher compared with that before treatment,the differences were statistically significant(P<0.05),and the differences were also statistically significant(P<0.05)when comparing the observation group with the control group.The visual analogue scoring method(VAS)scores of dysmenorrhea were significantly lower in both groups after treatment than that before treatment,and the difference was statistically significant(P<0.05)in the observation group compared with the control group.There was no statistically

关 键 词：子宫内膜异位症 促性腺激素释放激素激动剂 血小板衍生因子 人层粘连蛋白 

分 类 号：R711.74[医药卫生—妇产科学]