自拟养气健肺汤联合噻托溴铵治疗肺气虚证稳定期COPD的临床疗效  

Clinical Efficacy of Self-designed Yangqi Jianfei Decoction Combined with Tiotropium Bromide in the Treatment of Stable COPD with with lung qi deficiency

作　　者：林文娟[1] 兰岚[1] LIN Wen-juan;LAN Lan(The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine,Fujian Fuzhou 350000)

机构地区：[1]福建中医药大学附属第二人民医院,福建福州350000

出　　处：《深圳中西医结合杂志》2023年第8期5-7,共3页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

基　　金：福建省卫健委青年科研项目(2020QNA065)。

摘　　要：目的:探讨自拟养气健肺汤联合噻托溴铵治疗肺气虚证稳定期慢性阻塞性肺疾病(COPD)的疗效及安全性。方法:采用随机对照研究方法将2021年1月至2022年1月在福建中医药大学附属第二人民医院诊治的64例稳定期COPD患者分为对照组(噻托溴铵治疗)及观察组(自拟养气健肺汤联合噻托溴铵治疗),比较两组患者治疗前及治疗后肺功能、中医证候积分、6 min步行试验(6MWT)及COPD评分(CAT)的差异。结果:两组患者治疗后第1秒用力呼气容积(FEV1)、FEV1%、FEV1/用力肺活量(FVC)均较治疗前有不同程度提高,且观察组患者治疗后FEV1、FEV1%、FEV1/FVC均较对照组高,差异具有统计学意义(P<0.05)。两组患者治疗后中医证候积分均较治疗前有不同程度下降,且观察组患者治疗后中医证候积分较对照组低,差异具有统计学意义(P<0.05)。两组患者治疗后6MWT均较治疗前有不同程度提升,CAT评分较治疗前有不同程度降低,且观察组患者治疗后6MWT较对照组远,CAT评分较对照组低,差异具有统计学意义(P<0.05)。两组患者治疗中均未见明显不良反应。结论:自拟养气健肺汤联合噻托溴铵治疗可显著改善肺气虚证稳定期COPD患者心肺功能,减轻临床症状,提高生活质量,并具有高效安全等优点。Objective To investigate the efficacy and safety of self-designed Yangqi Jianfei decoction combined with Tiotropium bromide in the treatment of stable chronic obstructive pulmonary diseases(COPD)with lung qi deficiency.Methods 64 patients with stable COPD treated in the Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine from January 2021 to January 2022 were divided into a control group(tiotropium bromide treatment)and an observation group(self-designed Yangqi Jianfei decoction combined with tiotropium bromide treatment).The differences of lung function,traditional Chinese medical syndrome score,6 minutes walk test(6MWT)and COPD assessment test(CAT)were compared between the two groups before and after treatment.Results Forced expiratory volume in first second(FEV1),FEV1%and FEV1/forced vital capacity(FVC)after treatment in the two groups were improved in different degrees compared with before treatment,and FEV1,FEV1%and FEV1/FVC in the observation group were higher than those in the control group after treatment,the differences were statistically significant(P<0.05).The TCM syndrome scores of the two groups were decreased to different degrees after treatment,and the TCM syndrome score of the observation group was lower than that of the control group after treatment,the differences were statistically significant(P<0.05).Compared with before treatment,6MWT in the two groups was improved to different degrees,and CAT score decreased to different degrees.Moreover,6MWT in the observation group was further than that in the control group after treatment,and CAT score was lower than that in the control group,with statistical significance(P<0.05).No obvious adverse reaction was observed in the two groups.Conclusion Self-designed Yangqi Jianfei decoction combined with Tiotropium bromide can significantly improve the cardiopulmonary function,reduce clinical symptoms,improve quality of life in stable COPD with lung qi deficiency patients,and has the advantages of high efficiency and safet

关 键 词：慢性阻塞性肺疾病 自拟养气健肺汤 噻托溴铵 肺气虚证 

分 类 号：R563[医药卫生—呼吸系统]