人体血浆中多环芳烃及含氧多环芳烃的暴露特征及健康风险评估  

Exposure characteristics and health risk assessment of polycyclic aromatic hydrocarbons and oxygenated derivatives in human plasma

作　　者：李晨光[1] 李维霞 张璟 李彭辉[1] LI Chenguang;LI Weixia;ZHANG Jing;LI Penghui(Tianjin University of Technology,Tianjin,300382,China)

机构地区：[1]天津理工大学,天津300382

出　　处：《环境化学》2023年第6期1784-1791,共8页Environmental Chemistry

基　　金：博士后基金面上项目(2020M670667);天津市科技计划项目(21YDTPJC00280);中新天津生态城2019年度科技计划项目“中新生态城健康幼儿园室内空气污染物安全标准构建”资助.

摘　　要：为探究人体多环芳烃(PAHs)及含氧多环芳烃(OPAHs)的内暴露水平、来源及健康效应,本研究采集了天津市45名青年男性的血浆样本,使用气相色谱-质谱法检测多环芳烃及含氧多环芳烃的暴露浓度,利用特征比值法和主成分分析法对其来源及贡献率进行解析,并利用苯并[a]芘(BaP)毒性当量浓度和致癌风险模型对致癌健康风险进行评估.结果共检测出7种PAHs和6种OPAHs,检出率分别为17.8%—80.0%和28.9%—66.7%,ΣPAHs和ΣOPAHs平均浓度为24.8 ng·mL^(−1)和31.9 ng·mL^(−1);其中,二苯并(a,h)蒽(DBahA)和10H-9-蒽酮(ATO)的浓度水平最高(14.2 ng·mL^(−1)、27.1 ng·mL^(−1)),组成特征以低-中分子量物质为主.使用特征比值法和主成分分析法进行污染来源分析,结果表明,石油源和化石燃料的燃烧是人体血浆中PAHs的重要来源.通过致癌风险分析得出风险值(CR)介于10-4与10−6之间,表明血浆中的多环芳烃类物质存在潜在的致癌风险.To investigate the internal exposure level,sources,and health effects of polycyclic aromatic hydrocarbons(PAHs)and oxygenated-polycyclic aromatic hydrocarbons(OPAHs)in human,the plasma samples of 45 young men were collected in Tianjin.The concentrations of PAHs and OPAHs in human plasma were measured using gas chromatograph-mass spectrometer instrument(GC-MS).The sources of the PAHs were analyzed by using diagnostics ratios and the principal component analysis(PCA),and the health risk of PAHs was assessed by BaP equivalent concentrations(BaPeq)and cancer risk(CR).Seven PAHs and six OPAHs were detected in the plasma samples.The detection frequencies of PAHs and OPAHs were in the range of 17.8%—80.0%and 28.9%—66.7%,respectively.The average concentration ofΣPAHs andΣOPAHs were 24.8 ng·mL^(−1) and 31.9 ng·mL^(−1),DBahA,ATO were predominant species(14.2 ng·mL^(−1),27.1 ng·mL^(−1),respectively),and the ring distribution of the PAHs was dominated by low–medium molecular weight components.The results of the diagnostics ratios and PCA suggested that PAHs originated mostly from petroleum source and petroleum combustion.Based on cancer risk analysis,CR values was between 10-4 and 10−6,indicating the potential carcinogenic risk of PAHs and their derivatives in plasma.

关 键 词：多环芳烃 含氧多环芳烃 血浆 健康风险评估 

分 类 号：X820.4[环境科学与工程—环境工程] X592