高危妊娠剖宫产应用麦角新碱并缩宫素对遏制产后出血的临床研究  

Clinical Study on Curbing Postpartum Hemorrhage with Ergometrine Combined with Oxytocin in Cesarean Section of High-risk Pregnancy

作　　者：白宇[1] BAI Yu(Prenatal Diagnosis Center,Changchun Obstetrics and Gynecology Hospital,Changchun,Jilin Province,130042 China)

机构地区：[1]长春市妇产医院产前诊断中心,吉林长春130042

出　　处：《中外医疗》2023年第17期88-91,共4页China & Foreign Medical Treatment

基　　金：吉林省卫生计生科技创新自筹经费项目(2017ZC002)。

摘　　要：目的研究高危妊娠剖宫产应用麦角新碱并缩宫素对遏制产后出血的临床应用。方法随机选取2021年1月—2022年12月长春市妇产医院高危妊娠剖宫产产妇120例为研究对象,随机分为对照组(60例,缩宫素治疗)和观察组(60例,缩宫素+麦角新碱治疗)。对比两组止血效果、凝血功能指标、Hb、应激反应指标、不良反应。结果观察组产后30 min内出血量(257.98±40.11)mL、产后30 min~2 h出血量(100.53±20.75)mL、产后2~24 h出血量(56.75±9.25)mL均小于对照组,差异有统计学意义(t=19.321、25.313、22.005,P<0.05)。治疗后观察组的PT、TT、APTT短于对照组,FIB、NO、NE、Ang-Ⅱ低于对照组,D-D、Hb高于对照组,差异有统计学意义(P<0.05)。两组治疗后的Hb高于治疗前,NO、NE、Ang-Ⅱ低于治疗前,差异有统计学意义(P<0.05);两组的不良反应发生率对比,差异无统计学意义(P>0.05)。结论高危妊娠剖宫产应用麦角新碱并缩宫素对遏制产后出血的临床效果明显,可有效减少出血量,调节凝血功能,减轻应激反应,安全性较高。Objective To study the clinical application of ergometrine and oxytocin in high-risk pregnancy cesarean section to curb postpartum hemorrhage.Methods A total of 120 cesarean section women with high-risk pregnancy from January 2021 to December 2022 in Changchun Obstetrics and Gynecology Hospital were randomly selected as the study objects.They were randomly divided into the control group(60 cases,treated with oxytocin)and the observation group(60 cases,treated with oxytocin and ergometrine).The hemostatic effect,coagulation function index,Hb,stress response index,and adverse reactions between two groups were compared.Results The blood loss within 30 min postpartum of the observation group was(257.98±40.11)mL,the blood loss within 30 min to 2 h postpartum was(100.53±20.75)mL,and the blood loss within 2 h to 24 h postpartum was(56.75±9.25)mL,all of which were smaller than that of the control group,the difference was statistically significant(t=19.321,25.313,22.005,P<0.05).After treatment,PT,TT and APTT in observation group were shorter than those in control group,FIB,NO,NE and Ang-Ⅱwere lower than those in control group,and D-D and Hb were higher than those in control group,the differences were statistically significant(P<0.05).Hb in two groups after treatment was higher than before treatment,NO,NE and Ang-Ⅱwere lower than before treatment,the difference was statistically significant(P<0.05).The incidence of adverse reactions were compared between the two groups,the difference was not statistically significant(P>0.05).Conclusion The application of ergometrine and oxytocin in cesarean section of high-risk pregnancy has obvious clinical effect on curbing postpartum hemorrhage,which can effectively reduce the amount of bleeding,regulate blood coagulation function,reduce stress response,and has high safety.

关 键 词：高危妊娠 剖宫产 麦角新碱 缩宫素 产后出血 凝血功能 

分 类 号：R793.1[医药卫生—临床医学]