美罗培南药动学/药效学及特殊人群用药的研究进展  

Research progress in pharmacokinetics/pharmacodynamics and drug use of meropenem in special population

作　　者：徐红艳 黄健 武阿龙 徐丙发 XU Hongyan;HUANG Jian;WU Along;XU Bingfa(Dept.of Pharmacy,the Third Affiliated Hospital of Anhui Medical University,Hefei 230061,China;College of Pharmacy,Anhui Medical University,Hefei 230061,China)

机构地区：[1]安徽医科大学第三附属医院药学部,合肥230061 [2]安徽医科大学药学院,合肥230061

出　　处：《中国药房》2023年第13期1661-1664,共4页China Pharmacy

基　　金：安徽医科大学第三附属医院基础与临床合作研究提升计划培育专项(No.2022sfy016)。

摘　　要：美罗培南是治疗多药耐药菌感染的首选药物,已广泛应用于临床,但特殊人群的生理病理特征会对美罗培南的药动学/药效学(PK/PD)参数产生影响,临床应用时需根据患者特征制定个体化给药方案。因此,本文总结了美罗培南在特殊人群中的PK/PD特点和应用,推荐美罗培南在儿童患者中给予10~40 mg/kg,q8 h;在老年患者中给予1 g,q8~12 h;在肾功能不全、接受连续静脉-静脉血液滤过和连续静脉-静脉血液透析的患者中给予0.75 g,q8 h;在肾功能亢进患者中给予1 g,q8 h延长输注至3 h或2g,q8 h;在肝硬化患者中给予2 g负荷剂量后再给予1 g,q8 h。Meropenem is the first choice for the treatment of multi-drug-resistant bacterial infections,which has been widely used in clinical practice.However,the physiological and pathological characteristics of special populations have a significant impact on the pharmacokinetics/pharmacodynamics(PK/PD)parameters of meropenem,so it is necessary to develop individualized drug administration plan according to the characteristics of patients in clinical application.Therefore,this paper summarizes PK/PD characteristics and application of meropenem in special population,and recommends the dosage of meropenem as follows:10-40 mg/kg,q8 h for children;1 g,q8-12 h for elderly patients;0.75 g,q8 h for the patients with renal insufficiency who received continuous veno-venous hemofiltration and continuous veno-venous hemodialysis;1 g,q8 h prolonged infusion until 3 hours or 2 g,q8 h for patients with hyperrenal function;1 g,q8 h after 2 g loading dose for patients with cirrhosis.

关 键 词：美罗培南 药动学 药效学 药物相互作用 治疗药物监测 

分 类 号：R969.1[医药卫生—药理学] R978.1[医药卫生—药学]