阿芬太尼联合丙泊酚在宫腔镜手术静脉麻醉中的应用效果  

Application Effect of Alfentanil Combined with Propofol in Intravenous Anesthesia of Hysteroscopic Surgery

作　　者：陈响 郑宏 CHEN Xiang;ZHENG Hong(Changle District Maternal and Child Health Hospital of Fuzhou,Fuzhou 350200,China;不详)

机构地区：[1]福州市长乐区妇幼保健院,福建福州350200 [2]中国人民解放军联勤保障部队第九〇〇医院

出　　处：《中外医学研究》2023年第19期137-141,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:分析阿芬太尼联合丙泊酚在宫腔镜手术静脉麻醉中的应用效果。方法:选取2021年11月—2022年10月福州市长乐区妇幼保健院麻醉科收治的100例宫腔镜手术患者为研究对象。根据随机数表法将其分成A组与B组,各50例。A组静注枸橼酸舒芬太尼注射液联合丙泊酚,B组静注盐酸阿芬太尼注射液联合丙泊酚。比较两组麻醉效果,麻醉前、麻醉完成后、子宫颈扩张时、术毕时生命体征,术后2 h、6 h、12 h、24 h疼痛程度,术前、术后1 d心钠素及应激反应、神经递质及不良反应。结果:B组睫毛反射消失时间、苏醒时间和定向力恢复时间均早于A组,丙泊酚用量少于A组,差异有统计学意义(P<0.05)。B组麻醉完成后、子宫颈扩张时、术毕时的平均动脉压、心率均高于A组,差异有统计学意义(P<0.05)。B组术后2、6、12、24 h数字模拟评分法(NRS)评分低于A组,差异有统计学意义(P<0.05)。B组术后1 d皮质醇、心钠素、肾上腺素、去甲肾上腺素水平均低于A组,差异有统计学意义(P<0.05)。B组术后1 d乙酰胆碱、谷氨酸水平均高于A组,多巴胺水平低于A组,差异有统计学意义(P<0.05)。B组不良反应发生率低于A组,差异有统计学意义(P<0.05)。结论:阿芬太尼联合丙泊酚在宫腔镜手术静脉麻醉中的应用效果较好,可提高麻醉效果,稳定患者术中生命体征,减轻应激反应与术后疼痛,改善神经递质水平,且不良反应少。Objective:To analyze the application effect of Alfentanil combined with Propofol in intravenous anesthesia of hysteroscopic surgery.Method:A total of 100 patients undergoing hysteroscopic surgery admitted to the Department of Anesthesiology in Changle District Maternal and Child Health Hospital of Fuzhou from November 2021 to October 2022 were selected as the study objects.According to the method of random number table,the patients were divided into group A and group B,with 50 cases in each group.Group A was given Sufentanil Citrate Injection combined with Propofol intravenous injection,group B was given Alfentanil Hydrochloride Injection combined with Propofol intravenous injection.The anesthetic effect,vital signs before anesthesia,after anesthesia,at cervical dilation,at the end of surgery,pain degree of 2 h,6 h,12 h,24 h after surgery,atrial natriuretic peptide and stress response,neurotransmitter before and at 1 d after surgery and adverse reactions were compared between two groups.Result:The disappearance time of eyelash reflex,the recovery time and the orientation recovery time in group B were earlier than those in group A,and the dosage of Propofol was less than that in group A,the difference was statistically significant(P<0.05).The mean arterial pressure and heart rate of group B after anesthesia,at cervical dilation and at the end of surgery were higher than those of group A,and the differences were statistically significant(P<0.05).The numerical rating scale(NRS)scores of group B at 2 h,6 h,12 h and 24 h after surgery were lower than those of group A,and the differences were statistically significant(P<0.05).The levels of cortisol,atrial natriuretic peptide,epinephrine and norepinephrine in group B were lower than those in group A at 1 d after surgery,and the differences were statistically significant(P<0.05).The levels of acetylcholine and glutamate in group B at 1 d after were higher than those in group A,and the level of dopamine was lower than that in group A,the differences were statistically sig

关 键 词：阿芬太尼 丙泊酚 静脉麻醉 宫腔镜手术 麻醉效果 生命体征 

分 类 号：R614[医药卫生—麻醉学]