低分子量肝素钠联合酚妥拉明治疗妊娠期高血压的效果及对氧化应激的影响  

Effect of Low Molecular Weight Heparin Sodium Combined with Phentolamine in the Treatment of Pregnancy Hypertension and Its Influence on Oxidative Stress

作　　者：林娟娟 LIN Juanjuan(Jingmen Rehabilitation Hospital,Jingmen 448000,China)

机构地区：[1]荆门市康复医院,湖北荆门448000

出　　处：《中外医学研究》2023年第18期18-22,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨低分子量肝素钠联合酚妥拉明治疗妊娠期高血压的效果及对氧化应激的影响。方法:回顾性分析2019年1月—2022年1月于荆门市康复医院诊治的160例妊娠期高血压患者的临床资料。根据治疗方法将其分为观察组及对照组,各80例。两组均接受常规治疗,对照组给予酚妥拉明治疗,观察组给予低分子量肝素钠联合酚妥拉明治疗。比较两组治疗前及治疗1周后血压指标、氧化应激指标、血管内皮损伤指标、高迁移率族蛋白1(HMGB1)、脂联素(APN)及妊娠结局。结果:治疗1周后,两组收缩压(SBP)及舒张压(DBP)水平均降低,观察组SBP及DBP水平均低于对照组,差异有统计学意义(P<0.05)。治疗1周后,两组脂质过氧化物(LPO)及同型半胱氨酸(Hcy)水平均降低,谷胱甘肽过氧化物酶(GSH-Px)及超氧化物歧化酶(SOD)水平均升高,观察组LPO、Hcy低于对照组,GSH-Px、SOD高于对照组,差异有统计学意义(P<0.05)。治疗1周后,两组内皮素-1(ET-1)、组织型转谷氨酰胺酶(tTG)、可溶性血管内皮生长因子受体-1(sFlt-1)及可溶性内皮因子(sEng)水平均降低,观察组ET-1、tTG、sFlt-1及sEng水平均低于对照组,差异有统计学意义(P<0.05)。治疗1周后,两组HMGB1水平降低,观察组低于对照组,APN水平升高,观察组高于对照组,差异有统计学意义(P<0.05)。观察组不良妊娠结局发生率(2.50%)低于对照组(11.25%),差异有统计学意义(P<0.05)。结论:低分子量肝素钠联合酚妥拉明可降低妊娠期高血压患者的血压水平,减轻氧化应激反应,改善血管内皮损伤,调节HMGB1及APN水平,降低不良妊娠发生率,效果显著。Objective:To investigate the effect of Low Molecular Weight Heparin Sodium combined with Phentolamine in the treatment of pregnancy hypertension and its influence on oxidative stress.Method:The clinical data of 160 patients with pregnancy hypertension who were treated in Jingmen Rehabilitation Hospital from January 2019 to January 2022 were retrospectively analyzed.They were divided into observation group and control group according to treatment method,80 cases in each group.Both groups received conventional treatment,the control group was given Phentolamine treatment,the observation group was given Low Molecular Weight Heparin Sodium combined Phentolamine treatment.Blood pressure index,oxidative stress index,vascular endothelial injury index,high mobility group protein B1(HMGB1)and adiponectin(APN)before treatment and after 1 week of treatment,pregnancy outcome were compared between the two groups.Result:After 1 week of treatment,systolic blood pressure(SBP)and diastolic blood pressure(DBP)levels were decreased in both groups,and SBP and DBP levels in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After 1 week of treatment,the levels of lipid peroxide(LPO)and homocysteine(Hcy)in both groups were decreased,and the levels of glutathione peroxidase(GSH-Px)and superoxide dismutase(SOD)in both groups were increased,while LPO,Hcy levels in the observation group were lower than those in the control group,GSH-Px,SOD levels in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).After 1 week of treatment,the levels of endothelin-1(ET-1),tissue transglutaminase(tTG),soluble vascular endothelial growth factor receptor-1(sFlt-1)and soluble endothelial factor(sEng)were decreased in both groups,and the levels of ET-1,tTG,sFlt-1 and sEng in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After 1 week of treatment,the

关 键 词：妊娠期高血压 低分子量肝素钠 酚妥拉明 氧化应激 血管内皮损伤 

分 类 号：R714.246[医药卫生—妇产科学]