头面部带状疱疹神经痛的影响因素分析  

Analysis of influencing factors of herpes zoster-related neuropathic pain on the head and face

作　　者：孙慧雅 王军 袁涛 范婷 SUN Huiya;WANG Jun;YUAN Tao;FAN Ting(First Affiliated Hospital of Wannan Medical College,Wuhu 241000,China)

机构地区：[1]皖南医学院第一附属医院,安徽芜湖241000

出　　处：《皮肤性病诊疗学杂志》2023年第3期241-245,共5页Journal of Diagnosis and Therapy on Dermato-venereology

摘　　要：目的探讨头面部带状疱疹神经痛的影响因素,为临床对本病的诊治提供参考。方法对2021年1—12月皖南医学院第一附属医院住院的89例头面部带状疱疹及168例非头面部带状疱疹的临床资料进行回顾性分析,比较两组患者性别、年龄、发病诱因、基础疾病、皮损特点、入院时疼痛评分、皮损严重程度评分、中性粒细胞/淋巴细胞比率(NLR)、治疗及转归等,采用Pearson分析NLR与疼痛评分及皮损严重程度评分的相关性,通过logistic回归分析影响带状疱疹神经痛的危险因素。结果头面部带状疱疹患者与非头面部患者年龄、性别、入院时疼痛评分及皮损严重程度评分等差异均无统计学意义(均P>0.05)。头面部带状疱疹患者脓疱、血疱及坏死出现比例高于非头面部组(25.84%比15.48%,χ^(2)=4.05,P=0.044),入院时NLR高于非头面部组(4.11±1.62比2.35±1.51,t=6.27,P<0.05)。NLR与皮损严重程度评分是头面部带状疱疹急性期疼痛程度的独立影响因素(NLR:OR=1.758,95%CI:1.215~2.543;皮损严重程度:OR=1.418,95%CI:1.034~1.944);皮损严重程度评分是头面部带状疱疹后遗神经痛的独立影响因素(OR=1.846;95%CI:1.167~2.922)。结论头面部带状疱疹较非头面部患者炎症程度更高。NLR、皮损严重程度与头面部带状疱疹急性期神经痛相关;而皮损严重程度与头面部带状疱疹后遗神经痛相关。Objective To explore the influencing factors of herpes zoster neuralgia in order to provide reference for the diagnosis and the treatment of this disease.Methods We retrospectively analyzed 89 cases of craniofacial herpes zoster and 168 cases of non-craniofacial herpes zoster hospitalized in the First Affiliated Hospital of Wannan Medical College from January,2019 to December,2019.The demographic and clinical characteristics were compared between these two groups.Pearson analysis was used to determine the correlation between NLR and pain score and severity score of the skin lesions.Logistic regression was used to analyze the risk factors for herpes zoster neuralgia.Results There were no significant differences in age,gender,pain score and severity of skin lesions between the two groups when admitted to hospital.Patients with craniofacial herpes zoster had a higher rate of pustules,blood blister and necrosis than that with non-craniofacial herpes zoster(25.84%vs.15.48%,χ^(2)=4.05,P=0.044).Moreover,the NLR were higher in patients with craniofacial herpes zoster than that with non-craniofacial herpes zoster(4.11±1.62 vs.2.35±1.51,t=6.27,P<0.05)at admission to hospital.NLR and severity of skin lesions were independent influencing factors for the severity of pain in acute phase of craniofacial herpes zoster(OR=1.758,95%CI:1.215~2.543 for NLR;OR=1.418,95%CI:1.034~1.944 for severity of skin lesions).The severity of skin lesions was an independent influencing factor for postherpetic neuralgia of craniofacial herpes zoster(OR=1.846,95%CI:1.167~2.922).Conclusions Patients with craniofacial herpes zoster have more severe inflammation.NLR and the severity of skin lesions are correlated with acute herpetic neuralgia.The severity of skin lesions is correlated with postherpetic neuralgia.

关 键 词：头面部带状疱疹 中性粒细胞绝对值/淋巴细胞绝对值 带状疱疹后遗神经痛 

分 类 号：R752.12[医药卫生—皮肤病学与性病学]