水半夏与半夏镇咳祛痰作用分析  

Study and Analysis on Antitussive and Expectorant Effects of Typhonium Flagelliforme and Pineilia Ternata

作　　者：梁永娟 林雨丽 李芳婵 李锦清 苏静红 蒋林 林青华[1,2] Liang Yongjuan;Li Yuli;Li Fangchan;Li Jingqing;Su Jinghong;Jiang Lin;Lin Qinghua(College of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530200,China;Guangxi Zhuang Yao Medicine Center of Engineering and Technology,Guangxi University of Chinese Medicine,Nanning 530200,China;Teaching Experiment and Training Center,Guangxi University of Chinese Medicine,Nanning 530200,China;Guangxi Advanced Technical School of Industry and Trade,Yulin 537000,China)

机构地区：[1]广西中医药大学药学院,广西南宁530200 [2]广西中医药大学广西壮瑶药工程技术研究中心,广西南宁530200 [3]广西中医药大学教学实验实训中心,广西南宁530200 [4]广西工贸高级技工学校,广西玉林537000

出　　处：《亚太传统医药》2023年第7期38-42,共5页Asia-Pacific Traditional Medicine

基　　金：广西中医药大学青年基金:基于血清药物化学的水半夏止咳化痰药效物质基础研究(2021QN002)。

摘　　要：目的:比较水半夏、半夏及其炮制品的镇咳祛痰作用。方法:采用小鼠浓氨水引咳法和小鼠气管酚红分泌量法,以咳嗽潜伏期、咳嗽次数、咳嗽抑制率和酚红分泌量、祛痰指数为指标,比较水半夏、半夏的镇咳祛痰作用,比较姜水半夏、姜半夏在复方半夏片中的镇咳祛痰作用。结果:与对照组相比,水半夏、半夏均能显著延长小鼠咳嗽的潜伏期(P<0.05),减少咳嗽次数(P<0.001),增加小鼠气管的酚红分泌量(P<0.05);水半夏、半夏在镇咳祛痰方面,无显著差异(P>0.05),但水半夏的咳嗽抑制率和祛痰指数优于半夏。与对照组相比,姜半夏方及姜水半夏方均能显著延长小鼠咳嗽的潜伏期(P<0.001),减少咳嗽次数(P<0.001),增加小鼠气管的酚红分泌量(P<0.001);姜水半夏方的镇咳祛痰活性与姜半夏方相比无显著差异(P>0.05),但姜水半夏方的咳嗽抑制率和祛痰指数优于姜半夏方。结论:水半夏在镇咳祛痰作用方面具有替代半夏的潜力,值得进一步深入研究。Objective:To compare the antitussive and expectorant effects of Typhonium flagelliforme,Pinellia ternata and their processed products.Methods:The indexes of incubation period of cough,cough frequency,cough inhibition rate,phenol red secretion and expectorant index were used to compare the antitussive and expectorant effects of the Typhonium flagelliforme and Pinellia ternata,and their processed products in Fufang Banxia tablets by the cough model induced by ammonia as well as phenol red excretion in mice.Results:Compared with the control group,both Ty-phonium flagelliforme and Pinellia ternata could significantly prolong the incubation period of cough(P<0.05),re-duce the frequency of cough(P<0.001),and increase the amount of phenol red secreted in mice(P<0.05).There were no significant difference between Typhonium flagelliforme and Pinellia ternata in antitussive and expectorant effects(P>0.05),but the cough inhibition rate and expectorant index of Typhonium flagelliforme were better than Pinellia ternata.Compared with the control group,the ginger processed of Typhonium flagelliforme and Pinellia ter-nata could significantly prolong the incubation period of cough(P<0.001),reduce the frequency of cough(P<0.001),increase the amount of phenol red secreted in mice(P<0.001).There were no significant difference in antitus-sive and expectorant activity between the ginger processed of Typhonium flagelliforme and Pinellia ternata(P>O.O5),but the cough inhibition rate and expectorant index of ginger processed Typhonium flagelliforme were better than ginger processed Pinellia ternata in Fufang Banxia tablets.Conclusion:Typhonium flagelliforme has the poten-tial to replace Pinellia ternata in antitussive and expectorant effects,which is worth further study.

关 键 词：水半夏 半夏 镇咳 祛痰 复方半夏片 

分 类 号：R285.5[医药卫生—中药学]