妇血康颗粒联合米索前列醇治疗产后出血的临床研究  

Clinical study of Fuxuekang Granules combined with misoprostol in treatment of postpartum hemorrhage

作　　者：梁军 任璐 曹青 陶琳 陈华 康淑芳 LIANG Jun;REN Lu;CAO Qing;TAO Lin;CHEN Hua;KANG Shu-fang(Department of Pharmacy,the Second Children&Women’s Healthcare of Jinan City,Jinan 271100,China;Department of Obstetrics,the Second Children&Women’s Healthcare of Jinan City,Jinan 271100,China;Department of Gynaecology,the Second Children&Women’s Healthcare of Jinan City,Jinan 271100,China)

机构地区：[1]济南市第二妇幼保健院药剂科,山东济南271100 [2]济南市第二妇幼保健院产科,山东济南271100 [3]济南市第二妇幼保健院妇科,山东济南271100

出　　处：《现代药物与临床》2023年第6期1428-1432,共5页Drugs & Clinic

基　　金：山东省医药卫生科技发展计划项目(20204040136)。

摘　　要：目的探讨妇血康颗粒联合米索前列醇片治疗产后出血的临床疗效。方法选择2019年3月-2021年2月济南市第二妇幼保健院收治的96例产后出血患者,根据信封抽签法将患者分为对照组和治疗组,每组各48例。对照组患者饭前口服米索前列醇片,0.6 mg/次,1次/d。治疗组在对照组的基础上开水冲服妇血康颗粒,10 g/次,3次/d。两组均连续治疗7 d。观察两组的临床疗效,比较两组的2、24 h出血量与止血时间、凝血功能指标和血清一氧化氮(NO)、血清抗凝血酶-Ⅲ(ATⅢ)水平。结果治疗后,治疗组患者的治愈率(91.67%)高于对照组治愈率(66.67%),组间比较差异具有显著性(P<0.05)。治疗后,治疗组2、24 h出血量少于对照组,止血时间短于对照组(P<0.05)。治疗后,两组凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、凝血酶时间(TT)均显著下降,纤维蛋白原(FIB)升高(P<0.05),且治疗组PT、APTT、TT均明显低于对照组,FIB高于对照组(P<0.05)。治疗后,两组NO水平下降,AT-Ⅲ水平升高(P<0.05);治疗后,治疗组NO水平低于对照组,AT-Ⅲ水平高于对照组(P<0.05)。结论妇血康颗粒联合米索前列醇片治疗产后出血的止血效果良好,可有效改善机体凝血功能指标和NO、AT-Ⅲ水平,具有良好的临床应用价值。Objective To investigate the clinical efficacy of Fuxuekang Granules combined with Misoprostol Tablets in treatment of postpartum hemorrhage.Methods Patients(96 cases)with postpartum hemorrhage in the Second Children&Women’s Healthcare of Jinan City from March 2019 to February 2021 were divided into control and treatment groups according to the envelope drawing method,and each group had 48 cases.Patients in the control group were po administered with Misoprostol Tablets before dinner,0.6 mg/time,once daily.Patients in the treatment group were po administered with Fuxuekang Granules on the basis of the control group,10 g/time,three times daily.Patients in two groups were treated for 7 d.After treatment,the clinical efficacies were evaluated,and amount of bleeding and time to stop bleeding at 2 h and 24 h,the coagulation function indexes,the serum levels of NO and AT-Ⅲ in two groups were compared.Results After treatment,the cure rate of the treatment group(91.67%)was higher than that of the control group(66.67%)with significant difference(P<0.05).After treatment,the blood loss at 2 h and 24 h in the treatment group was less than that in the control group,and the time of hemostasis in the treatment group was shorter than that in the control group(P<0.05).After treatment,PT,APTT,and TT in two groups were significantly decreased,but FIB were significantly increased(P<0.05).And PT,APTT,and TT in the treatment group were significantly lower than those in the control group,but FIB were significantly higher than those in the control group(P<0.05).After treatment,the levels of NO in two groups were decreased,but the levels of AT-Ⅲ in two groups were increased(P<0.05).After treatment,the levels of NO in the treatment group were lower than those in the control group,but the levels of AT-Ⅲ in the treatment group were higher than those in the control group(P<0.05).Conclusion Fuxuekang Granules combined with Misoprostol Tablets have good hemostatic effect in treatment of postpartum hemorrhage,can effectively improve the

关 键 词：妇血康颗粒 米索前列醇片 产后出血 出血量 止血时间 凝血酶原时间 活化部分凝血酶原时间 凝血酶时间 纤维蛋白原 一氧化氮 抗凝血酶-Ⅲ 

分 类 号：R984[医药卫生—药品]