双氢青蒿素防治乳腺癌作用机制的研究进展  

Research progress on mechanism of dihydroartemisinin in prevention and treatment of breast cancer

作　　者：刘忠丽[1] 李棠姗 张羽[1] 蒲静[1] 何成伟[1] 巩子星 LIU Zhong-li;LI Tang-shan;ZHANG Yu;PU Jing;HE Cheng-wei;GONG Zi-xing(Department of Oncology,Mianyang Central Hospital,Mianyang 621000,China;Department of General Surgery,Hebei Hospital of Traditional Chinese Medicine,Shijiazhuang 050000,China)

机构地区：[1]绵阳市中心医院肿瘤科,四川绵阳621000 [2]河北省中医院普外科,河北石家庄050000

出　　处：《现代药物与临床》2023年第6期1537-1542,共6页Drugs & Clinic

基　　金：河北省中医药管理局科研计划项目(2019005)。

摘　　要：乳腺癌是最常见的癌症之一,属于典型的异质性恶性肿瘤,临床结局不佳。双氢青蒿素是青蒿素在体内的主要代谢产物,可抑制乳腺癌肿瘤细胞增殖、促进肿瘤细胞凋亡、阻止肿瘤细胞转移、诱导细胞自噬,因此对双氢青蒿素抗乳腺癌的作用机制进行总结,希望为双氢青蒿素的临床使用提供参考。Breast cancer,one of the most common cancers,is a typical heterogeneous malignancy with poor clinical outcome.Dihydroartemisinin is the main metabolite of artemisinin in vivo.Dihydroartemisinin can inhibit the proliferation of breast cancer tumor cells,promote tumor cell apoptosis,prevent tumor cell metastasis,and induce autophagy.This article summarizes the mechanism of dihydroartemisinin against breast cancer,hoping to provide reference for the clinical use of dihydroartemisinin.

关 键 词：双氢青蒿素 乳腺癌 细胞增殖 细胞凋亡 细胞转移 细胞自噬 

分 类 号：R979.1[医药卫生—药品]