桦木酸抗乳腺癌的作用机制研究进展  

Advances on mechanism of betulinic acid against breast cancer

作　　者：郭静华 赵振亚[2] 朱军平 宋志岗 GUO Jing-hua;ZHAO Zhen-ya;ZHU Jun-ping;SONG Zhi-gang(Department of Pathology,Xingtai City Fifth Hospital,Xingtai 054000,China;Department of Pathology,Xingtai People's Hospital,Xingtai 054000,China;Cardiothoracic Surgery,Xingtai General Hospital of North China Medical and Health Group,Xingtai 054000,China;Department of Oncology,Xingtai Third Hospital,Xingtai 054000,China)

机构地区：[1]邢台市第五医院病理科,河北邢台054000 [2]邢台市人民医院病理科,河北邢台054000 [3]华北医疗健康集团邢台总医院心胸外科,河北邢台054000 [4]邢台市第三医院肿瘤科,河北邢台054000

出　　处：《现代药物与临床》2023年第6期1543-1548,共6页Drugs & Clinic

基　　金：邢台市科技计划项目(2019ZC345)。

摘　　要：乳腺癌是影响全球女性的最常见恶性肿瘤之一,化疗药物的耐药性已成为乳腺癌治疗中最常见的挑战之一。桦木酸是一种天然存在的三萜类化合物,具有多种药理作用。桦木酸能通过抑制乳腺癌肿瘤细胞增殖和生长、促使肿瘤细胞凋亡、抑制肿瘤细胞侵袭和转移、抑制炎症反应以及与其他药物协同抗肿瘤等多个作用机制发挥抗乳腺癌的作用,因此综述了桦木酸抗乳腺癌的作用机制,以期为桦木酸的临床使用提供参考。Breast cancer is one of the most common malignant tumors affecting women worldwide,and the drug resistance of chemotherapy has become one of the most common challenges in the treatment of breast cancer.Betulinic acid is a naturally occurring triterpenoid compound with various pharmacological effects.Betulinic acid can play an anti-tumor role in breast cancer by inhibiting the proliferation and growth of tumor cells,promoting the apoptosis of tumor cells,inhibiting the invasion and metastasis of tumor cells,inhibiting inflammatory reaction,and playing a synergistic anti-tumor role with other drugs and other mechanisms.This article reviews the mechanism of betulinic acid against breast cancer,in order to provide reference for the clinical use of betulinic acid.

关 键 词：桦木酸 乳腺癌 细胞增殖 细胞凋亡 细胞侵袭 细胞转移 炎症反应 协同作用 

分 类 号：R979.1[医药卫生—药品]