In vivo activities of the structured lipids-1,3-dioleic acid 2-palmitic acid triglyceride(OPO)in high-fat diet mice  

作　　者：Yuyang Huang Na Wang Haitian Zhao 

机构地区：[1]College of Food Engineering,Harbin University of Commerce,Harbin,Heilongjiang,150028,China [2]College of Food Science,Northeast Agricultural University,Harbin,Heilongjiang,150030,China [3]National Research Center of Soybean Engineering and Technology,Harbin,Heilongjiang,150027,China [4]Department of Food Sciences and Engineering,School of Chemistry and Chemical Engineering,Harbin Institute of Technology,Harbin,Heilongjiang,150001,China

出　　处：《Food Bioscience》2022年第3期615-624,共10页食品生物科学（英文）

基　　金：the financial support received from the National Key Research and Development projects(2017YFD0400200).

摘　　要：High-energy diets and lipid metabolism can lead to high levels of total cholesterol,a decrease in antioxidant,enzyme activity,and an increase in oxidative stress and dyslipidemia biomarker.In this study,the in vivo antihyperlipidemic and antioxidant effects of 1,3-dioleoyl-2-palmitoyl triglyceride(OPO)using a high fat-diet model were investigated.The mice were divided into groups including high-fat model group(HF),auxiliary group(AG),positive Control group(PC),low OPO dose group(LO),medium OPO dose group(MO)and high OPO.OPO was administrated to 60 hyperlipidemia induced male Kunming mice at the dosage of 200,400 and 800 mg/kg•d body weight,for 35 days.The results showed that the administration of OPO decreased the body weight from 43.92 g in HF to 37.74 g in HO group,liver index from 3.94%in HF to 3.43 in HO group and kidney index from 1.38 in HF%to 1.17%in HO group.The administration of OPO significantly decreased hyperlipidemia mice's serum triglyceride,total cholesterol,and low-density lipoprotein cholesterol levels at P<0.05.High-density lipoprotein cholesterol levels were increased with reductions of visceral hypertrophy and fat accumulation in model mice.Furthermore,in the HO group,superoxide dismutase,catalase and glutathione peroxidase levels increased significantly by 27.39,38.33 and 22.90%at(P<0.05),respectively.OPO also significantly reduced the enzyme activity of aspartate aminotransferase and alanine aminotransferase in serum at P<0.05.These findings suggested that OPO has potential use in hyperlipidemia treatment and other health-related complications.

关 键 词：1 3-Dioleoyl-2-palmitoyl triglyceride ANTIHYPERLIPIDEMIC Antioxidant In vivo High-fat diet 

分 类 号：R285[医药卫生—中药学]