宁波市2013—2021年发热伴血小板减少综合征流行病学特征  

Epidemiological characteristics of severe fever with thrombocytopenia syndrome in Ningbo city,2013-2021

作　　者：莫琼 李永东[1] 焦素黎[1] 王蓉[1] 张栋梁[1] 倪红霞[1] Mo Qiong;Li Yongdong;Jiao Suli;Wang Rong;Zhang Dongliang;Ni Hongxia(Ningbo Municipal Center for Disease Control and Prevention,Ningbo 315010,China)

机构地区：[1]宁波市疾病预防控制中心,宁波315010

出　　处：《中华实验和临床病毒学杂志》2023年第3期320-325,共6页Chinese Journal of Experimental and Clinical Virology

基　　金：宁波市医疗卫生品牌学科(PPXK2018-10);浙江省传染病疫苗与预防控制研究重点实验室开放基金(2021-01)。

摘　　要：目的了解宁波市2013—2021年发热伴血小板减少综合征(severe fever with thrombocytopenia syndrome,SFTS)的流行特征。方法系统收集并分析近10年来宁波市SFTS报告病例的个案资料、病原学检测数据及病原基因组测序数据。结果2013—2021年,宁波市共报告SFTS 65例,死亡8例,病死率12.31%。患者平均年龄为53.65岁,60~70岁年龄组患者最多。宁波市下辖10个区(县)中6个区(县)有SFTS病例报告,以宁海县(33例,50.77%)和象山县(20例,30.77%)报告病例最多。发病时间呈季节性分布,7月为发病高峰,4~8月病例占全年病例数的81.54%(53/65)。76.92%(50/65)病例为农民。92.31%(60/65)病例居住在山区或丘陵地区。65例SFTS病例中,8例患者有明确蜱虫叮咬史,20例患者接触家养动物(宠物)或居住地有鼠类出没。基因测序结果显示,宁波市发热伴血小板减少综合征病毒(severe fever with thrombocytopenia syndrome virus,SFTSV)流行株为J2基因型和C4基因型。结论宁波市SFTS患者多为老年农民,宁海县和象山县为高发地区,7月为发病高峰月,J2型和C4型为主要流行株。Objective To disclose the epidemiological characteristics of severe fever with thrombocytopenia syndrome in Ningbo city from 2013 to 2021.Methods Epidemic data and laboratory-confirmed results of SFTS patients in Ningbo city were analyzed in the past 10 years.Phylogenetic trees were constructed by using genomic sequences of severe fever with thrombocytopenia syndrome virus(SFTSV)strains isolated from the patients.Results During 2013-2021,a total of 65 confirmed SFTS cases were reported with the mortality of 12.31%,including 8 dead cases.The average age was 53.65 years with higher incidence in 60-70 years old cases.Cases were reported in 6 districts(counties)from Ningbo city,of which Ninghai county(33 cases,50.77%)and Xiangshan county(20 cases,30.77%)reported the highest number of cases.The cases mainly occurred from April to August,accounting for 81.54%(53/65);76.92%(50/65)of the patients were farmers;92.31%(60/65)of patients lived in mountainous or hilly terrain.Of the 65 SFTS cases,8 patients had a clear history of tick bites,and 20 patients had contact with domestic animals(pets)or rats in their residence.The evolution analysis on gene sequencing results showed that SFTSV epidemic strains in Ningbo city included genotype J2 and C4.Conclusion Most of the SFTS patients were elderly people.The top two high-risk areas were Ninghai county and Xiangshan county.July was the peak month of the disease.Genotype J2 and C4 were epidemic strains in Ningbo city.

关 键 词：发热伴血小板减少综合征 流行病学 基因型 

分 类 号：R512.8[医药卫生—内科学] R181.3[医药卫生—临床医学]