布鲁氏菌鞭毛和毒力因子及疫苗研究进展  

Progress on Flagella,Virulence Factors and Vaccines of Brucella

作　　者：常攀 边巴央拉 索朗斯珠 罗润波 娄永志 辛娇娇 贡嘎 CHANG Pan;BIANBA Y L;SUOLANG S Z;LUO Run-bo;LOU Yong-zhi;XIN Jiao-jiao;GONG Ga(College of Animal Science,Tibet College of Agriculture and Animal Husbandry,Nyingchi,Tibet,860000,China;Animal Disease Prevention and Control Center of Tibet Autonomous Region,Lhasa,Tibet,850000,China)

机构地区：[1]西藏农牧学院动物科学学院,西藏林芝860000 [2]西藏自治区动物疫病预防控制中心,西藏拉萨850000

出　　处：《动物医学进展》2023年第8期82-90,共9页Progress In Veterinary Medicine

基　　金：国家现代农业产业技术体系资助项目(CARS-37);西藏自治区2021年自然科学基金项目(XZ202101ZR0056G)。

摘　　要：布鲁氏菌病是一种重要的人兽共患病,在全球范围内造成了巨大的经济损失和公共卫生问题。近年来,我国布鲁氏菌病仍没有得到很好的控制,目前尚无国际上认可的人用布鲁氏菌疫苗,动物布鲁氏菌疫苗在近几十年布鲁氏菌病防控中起着重要作用,但仍存在一些不足。论文综述了布鲁氏菌鞭毛的组成结构和鞭毛蛋白的作用与功能、毒力因子和疫苗研发等方面的研究进展,为后续布鲁氏菌致病性的分子机制研究和疫苗研发提供参考。Brucellosis is an important zoonotic disease,which has caused huge economic losses and public health problems worldwide.In recent years,brucellosis has been on the rise in China,and there is currently no internationally recognized brucellosis vaccine for humans.Animal Brucella vaccines have played an important role in the prevention and control of brucellosis in recent decades,but there are still some shortcomings.This paper summarizes the research progress on the composition and structure of Brucella flagella,the role and function of flagellin,virulence factors and vaccine development,and provides reference for the subsequent research on the molecular mechanism of Brucella pathogenicity and vaccine development.

关 键 词：布鲁氏菌 鞭毛结构和作用 鞭毛蛋白 毒力因子 免疫逃避 疫苗研发 

分 类 号：S852.614[农业科学—基础兽医学]