阿托伐他汀联合诺欣妥治疗冠心病经皮冠状动脉介入术后心绞痛对血脂水平及内皮功能的影响  

Effects of Atorvastatin Combined with Entresto on Blood Lipid Levels and Endothelial Function in Patients with Angina Pectoris after Percutaneous Coronary Intervention for Coronary Heart Disease

作　　者：李医博 刘志强[1] 赵利培 张芙成[1] LI Yi-bo;LIU Zhi-qiang;ZHAO Li-pei;ZHANG Fu-cheng(The fourth Ward of Department of Cardiology,Xinxiang Central Hospital,Xinxiang 453001)

机构地区：[1]新乡市中心医院心血管内科四病区,新乡453001

出　　处：《四川解剖学杂志》2023年第1期90-92,104,共4页Sichuan Journal of Anatomy

摘　　要：目的:探讨阿托伐他汀联合诺欣妥较(沙库巴曲缬沙坦钠)治疗冠心病经皮冠状动脉介入治疗(PCI)术后心绞痛对血脂水平和内皮功能的影响.方法:回顾性分析2021年5月至2022年5月于本院行PCI术后发生心绞痛的168例冠心病患者临床资料.根据治疗方案分为观察组(n=87)和对照组(n=81).观察组采取阿托伐他汀联合诺欣妥治疗,对照组采取阿托伐他汀治疗.比较两组临床疗效、血清血脂水平、炎性因子水平、血管内皮功能及不良反应.结果:观察组总有效率高于对照组,差异具有统计学意义(P<0.05).观察组治疗后总胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白胆固醇(LDL-C)、超敏C反应蛋白(hs-CRP)、白细胞介素(IL)-10水平均低于对照组,高密度脂蛋白胆固醇(HDL-C)水平高于对照组,一氧化氮(NO)含量均高于对照组,内皮素-1水平低于对照组,差异均具有统计学意义(P<0.05).两组不良反应总发生率比较,差异无统计学意义(P>0.05).结论:阿托伐他汀联合诺欣妥治疗冠心病PCI术后心绞痛治疗效果更显著,能有效调节血脂水平,改善血管内皮功能.Objective:Exploring the effects of atorvastatin combined with entresto(sacubitril valsartan sodium)on blood lipid levels and endothelial function in the treatment of angina pectoris after percutaneous coronary intervention(PCI)in patients with coronary heart disease.Methods:A total of 168 patients with coronary heart disease who developed angina pectoris after PCI in our hospital from May 2021 to May 2022 were selected.According to different treatment plans,they were divided into observation group(n=87)and control group(n=81).The observation group were treated with atorvastatin calcium combined with entresto tablets,and the control group were treated with atorvastatin calcium.The clinical efficacy,serum lipid levels,inflammatory factor levels,vascular endothelial function,and adverse reactions were compared between the two groups.Results:The total effective rate in the observation group was higher than that in the control group(P<0.05).After the treatment,the levels of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),hypersensitive C-reactive protein(hs-CRP)and interleukin(IL)-10 in the observation group were lower than those in the control group,and the level of high density lipoprotein cholesterol(HDL-C)was higher than that in the control group(P<0.05).After treatment,the contents of nitric oxide(NO)in the observation group were higher than those in the control group,and the level of endothelin-1 was lower than that in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:The treatment effects of atorvastatin combined with entresto on angina pectoris after coronary heart disease PCI is more significant,which can effectively regulate blood lipid levels and improve vascular endothelial function.

关 键 词：冠心病 经皮冠状动脉介入 术后心绞痛 诺欣妥 

分 类 号：R541.4[医药卫生—心血管疾病]