氧化应激在重型创伤性脑损伤及其并发症中作用机制的研究进展  

Mechanism of action of oxidative stress in severe traumatic brain injury and its complications:recent progress

作　　者：王晓霞 方向明[1] 骆建军 邓勇 Wang Xiaoxia;Fang Xiangming;Luo Jianjun;Deng Yong(Department of Anesthesiology,First Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310011,China;Department of Critical Care Medicine(War Trauma Emergency Center),No.903 Hospital of PLA Joint Logistics Support Force,Hangzhou 310000,China;Department of Neurosurgery,No.903 Hospital of PLA Joint Logistic Support Force,Hangzhou 310000,China)

机构地区：[1]浙江大学医学院附属第一医院麻醉科,杭州310011 [2]中国人民解放军联勤保障部队第九〇三医院重症医学科(战创伤急救中心),杭州310000 [3]中国人民解放军联勤保障部队第九〇三医院神经外科,杭州310000

出　　处：《中华创伤杂志》2023年第6期558-569,共12页Chinese Journal of Trauma

基　　金：2020年度杭州市卫生科技计划(B20200452)。

摘　　要：重型创伤性脑损伤(sTBI)具有病情危重、致死性强、预后多不良的特点,其发生发展会导致大量神经细胞损伤和死亡,进而引发一系列严重并发症。目前sTBI及其并发症救治总体情况不乐观,存在作用机制和治疗方法不明确、缺乏有效预防策略等问题。近年来,越来越多的研究证据表明,氧化应激反应在sTBI及其相关并发症的发生发展过程中发挥着重要作用。因此,明确氧化应激与sTBI及其并发症的关系、阐述氧化应激如何参与该类疾病的发生与发展过程具有重大意义。然而,目前该类相关研究资料较分散,缺乏对氧化应激在sTBI及其并发症发生发展中的参与过程全面、系统地归纳总结。为此,笔者就氧化应激在sTBI及其并发症中作用机制的研究进展进行综述,为该系列疾病的研究、救治及预防提供参考。Severe traumatic brain injury(sTBI)is characterized by critical condition,high lethality and poor prognosis.Its development and progression will lead to the damage and death of a large number of nerve cells,eventually causing a series of serious complications.The current treatments of sTBI and its complications are not optimistic due to problems such as unclear mechanism of action,challenges in treatment,and lack of effective prevention strategies.In recent years,more research evidences have shown that oxidative stress plays an important role in the development and progression of sTBI and its related complications.Therefore,it is of great significance to clarify the relationship of oxidative stress with sTBI and its complications and to understand the way of oxidative stress participating in the development and progression of sTBI.However,relevant researches are scattered and there lacks comprehensive and systematic summaries of oxidative stress participating in sTBI and its related complications.To this end,the authors reviewed the progress of the mechanism by which oxidative stress involves in sTBI and its complications,hoping to provide references for the research,treatment and prevention of sTBI.

关 键 词：脑损伤 创伤性 氧化性应激 癫痫 创伤后 颅内高压 脑梗死 消化性溃疡出血 

分 类 号：R651.15[医药卫生—外科学]