严重急性呼吸系统综合征冠状病毒2感染/疫苗接种引起的免疫印记  

Immune imprinting caused by infection/vaccination of severe acute respiratory syndrome coronavirus 2

作　　者：于永利[1] YU Yong-li(Department of Immunology,School of Basic Medical Sciences,Jilin University,Changchun 130021,Jilin Province,China)

机构地区：[1]吉林大学基础医学院免疫系,吉林长春130021

出　　处：《微生物学免疫学进展》2023年第3期1-5,共5页Progress In Microbiology and Immunology

摘　　要：先前发生的病毒感染或疫苗接种引起的免疫应答,强烈影响机体对该病毒后续暴露的免疫应答,这种现象被称为免疫印记。免疫印记也可出现在感染严重急性呼吸综合征冠状病毒2(severe acute respiratory syndrome corona-virus 2,SARS-CoV-2)或接种SARS-CoV-2疫苗的个体。发生了免疫印记的个体对再次遇到的完全相同的SARS-CoV-2毒株发动更强的免疫反应,而对新暴露的SARS-CoV-2变异株仅能发动微弱的免疫反应。免疫印记是SARS-CoV-2变异株在以前感染SARS-CoV-2或接种SARS-CoV-2疫苗的人群形成突破感染的一个不可忽略的原因。克服免疫印记是研制能预防未来SARS-CoV-2突变株感染的SARS-CoV-2疫苗的迫切任务。Immune responses to infection by subsequent severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)strains depends strongly on previous infections or vaccinations,which is designated as immune imprinting.The immune system responds more strongly to the strain of a SARS-CoV-2 or SARS-CoV-2 specific antigens in vaccines it first met,weakening response to the other newly exposed strains.This immune imprinting contributes to the breakthrough infection of SARSCoV-2 variants in people previously infected with SARS-CoV-2 or vaccinated with SARS-CoV-2 vaccine.How to overcome the immune imprinting is required to develop new versions of SARS-CoV-2 vaccines to induce prophylactic immunity to future coming mutant SARS-CoV-2.

关 键 词：严重急性呼吸系统综合征冠状病毒2 感染 疫苗 免疫印记 

分 类 号：R512.99[医药卫生—内科学]