血清sdLDL-C、ApoAⅠ和ApoB水平对冠心病急性冠状动脉综合征的预测价值  

Predictive value of serum sdLDL-C,ApoA I and ApoB levels in acute coronary syndrome of coronary heart disease

作　　者：杜鹏 张向立[1] 朱勇锋[1] DU Peng;ZHANG Xiang-li;ZHU Yong-feng(Zhengzhou Seventh People's Hospital,Henan 450000,China)

机构地区：[1]郑州市第七人民医院,河南450000

出　　处：《中国卫生检验杂志》2023年第9期1107-1110,共4页Chinese Journal of Health Laboratory Technology

摘　　要：目的 探讨血清小而密低密度脂蛋白胆固醇(sdLDL-C)、载脂蛋白AⅠ(ApoAⅠ)和载脂蛋白B(ApoB)水平对冠心病急性冠状动脉综合征(ACS)的预测价值。方法 选取本院收治的219例冠心病患者(冠心病组),并根据冠心病临床分类将其分为ACS组与稳定性冠心病组,另选取同期体检健康者201例(健康组)。对比各组血清sdLDL-C、ApoAⅠ、ApoB水平,分析上述指标与冠心病ACS的关系,采用受试者工作曲线(ROC)分析三者联合对冠心病ACS的预测价值。结果 冠心病组血清sdLDL-C、ApoB水平均高于健康组,ApoAⅠ水平低于健康组(P<0.05);ACS组血清sdLDL-C、ApoB水平均高于稳定性冠心病组,ApoAⅠ水平低于稳定性冠心病组(P<0.05);多因素logistic回归性分析显示,高血压及血清sdLDL-C、ApoB、ApoAⅠ水平均是冠心病ACS的影响因素(P<0.05);根据ROC曲线分析,血清sdLDL-C、ApoAⅠ、ApoB水平联合预测冠心病ACS的灵敏度与曲线下面积(AUC)均高于单项预测(P<0.05),特异度与单项预测比较差异无统计学意义(P>0.05)。结论 血清sdLDL-C、ApoB、ApoAⅠ水平均对冠心病ACS具有一定的预测价值,但此三者联合时对其的预测效能更佳,可据此指导临床诊治与防控。Objective This paper aims to investigate the predictive value of serum small and dense low density lipoprotein cholesterol(sdLDL-C),apolipoprotein AI(ApoA I)and apolipoprotein B(ApoB)levels in acute coronary syndrome(ACS)of coronary heart disease.Methods A total of 219 patients with coronary heart disease(coronary heart disease group)were selected,who were divided into ACS group and stable coronary heart disease group according to the clinical classification of coronary heart disease,and another 201 healthy people(healthy group)were selected in the same period.The serum levels of sdLDL-C,ApoA I and ApoB were compared among the groups,the relationships between the above indexes and ACS of coronary heart disease were analyzed,and the predictive value of the combination of the three in ACS of coronary heart disease was analyzed by receiver operating curve(ROC).Results The levels of sdLDL-C and ApoB in coronary heart disease group were higher than those in healthy group,but ApoA I level was lower than that in healthy group(P<0.05).The serum levels of sdLDL-C and ApoB in the ACS group were higher than those in the stable coronary heart disease group,but the level of ApoA I was lower than that in the stable coronary heart disease group(P<0.05).Multivariate logistic regression analysis showed that hypertension and the serum levels of sdLDL-C,ApoB and ApoA I were the influencing factors of coronary heart disease in ACS(P<0.05).According to ROC curve analysis,the sensitivity and area under curve(AUC)of combination of serum sdLDL-C,ApoB and ApoA I levels in predicting ACS of coronary heart disease were higher than those of single prediction(P<0.05),and there was no statistical significance on the difference in specificity between combined prediction and single prediction(P>0.05).Conclusion The serum levels of sdLDL-C,ApoB and ApoA I all have a certain predictive value for ACS of coronary heart disease,but the combination of the three has a better predictive effect for it,which can guide clinical diagnosis,treatment and pre

关 键 词：小而密低密度脂蛋白胆固醇 载脂蛋白AⅠ 载脂蛋白B 冠心病 急性冠状动脉综合征 

分 类 号：R541[医药卫生—心血管疾病]