868例乳腺脓液标本病原菌分布和耐药性分析  

Distribution and drug resistance of pathogens in 868 cases of breast pus

作　　者：游星兰 刘鹏鹏 任建敏[1] 赵芯米 赵志钢[1] 丁卉[1] YOU Xing-lan;LIU Peng-peng;REN Jian-min;ZHAO Xin-mi;ZHAO Zhi-gang;DING Hui(Clinical Laboratory,Lishui Central Hospital,Zhejiang 323000,China)

机构地区：[1]丽水市中心医院检验科,浙江323000 [2]丽水市中心医院乳腺外科

出　　处：《中国卫生检验杂志》2023年第11期1315-1318,共4页Chinese Journal of Health Laboratory Technology

基　　金：丽水市科技计划项目(2020ZDYF11)。

摘　　要：目的分析乳腺疾病患者乳腺脓液标本的病原菌分布和对常见抗菌药物的耐药性,为临床治疗提供依据。方法回顾分析2017年—2021年丽水市中心医院乳腺外科门诊和病房送检的乳腺脓液标本病原菌及其药敏结果。结果868份标本病原菌检出率为33.5%(291/868),以金黄色葡萄球菌和克罗彭施泰特棒杆菌为主,分别占33.3%(97/291)和33.0%(96/291),其中耐甲氧西林金黄色葡萄球菌(MRSA)占10.7%(31/291)。金黄色葡萄球菌对青霉素G、红霉素和克林霉素耐药率分别为87.63%、58.76%和26.80%,MRSA对青霉素G、红霉素、克林霉素耐药率高于非耐甲氧西林金黄色葡萄球菌(MSSA)、凝固酶阴性葡萄球菌(CNS)(P<0.05)。克罗彭施泰特棒杆菌对青霉素G、红霉素和克林霉素耐药率分别为13.68%、60.00%和54.73%。结论不同乳腺疾病患者病原菌分布有差异,不同病原菌的耐药情况有所不同,为提高早期治疗效果应尽早送检标本培养。Objective This paper aims to analyze the distribution of pathogens in breast pus samples of patients with breast dis⁃eases and their resistance to common antibiotics,so as to provide basis for clinical treatment.Methods Retrospective analysis was performed on pathogenic bacteria and their drug sensitivity results in breast pus specimens sent to the breast surgery clinic and ward of Lishui Central Hospital from 2017 to 2021.Results The detection rate of pathogenic bacteria in 868 samples was 33.5%(291/868),with Staphylococcus aureus and Corynebacterium kroppenstedtii predominating,respectively accounting for 33.3%(97/291)and 33.0%(96/291),of which Methicillin-resistant Staphylococcus aureus(MRSA)accounted for 10.7%(31/291).The resistance rates of Staphylococcus aureus to penicillin G,erythromycin,and clindamycin were 87.63%,58.76%,and 26.80%,respectively.The resistance rates of MRSA to penicillin G,erythromycin,and clindamycin were significantly higher than those of non-methicillin resistant Staphylococcus aureus(MSSA)and coagulase negative Staphy⁃lococcus(CNS)(P<0.05).The resistance rates of Corynebacterium kroppenstedtii to penicillin G,erythromycin,and clinda⁃mycin were 13.68%,60.00%,and 54.73%,respectively.Conclusion The distribution of pathogenic bacteria varies among patients with different breast diseases,and the drug resistance of different pathogens varies,so specimens should be sent for cul⁃ture as early as possible to improve the effect of early treatment.

关 键 词：乳腺脓液 金黄色葡萄球菌 克罗彭施泰特棒杆菌 耐药性 

分 类 号：R446.5[医药卫生—诊断学]