Metagenomic next-generation sequencing in the diagnosis of neurocysticercosis:A case report  

作　　者：Wen-Bin Xu Juan-Juan Fu Xiao-Ju Yuan Qing-Jie Xian Li-Jun Zhang Ping-Ping Song Zhi-Qing You Cheng-Tan Wang Qi-Gang Zhao Feng Pang 

机构地区：[1]Department of Clinical Laboratory,Liaocheng People’s Hospital,Liaocheng 252000,Shandong Province,China [2]Department of Gastroenterology,Liaocheng People’s Hospital,Liaocheng 252000,Shandong Province,China [3]Department of Neurology,Liaocheng People’s Hospital,Liaocheng 252000,Shandong Province,China

出　　处：《World Journal of Clinical Cases》2023年第20期4912-4919,共8页世界临床病例杂志

摘　　要：BACKGROUND The clinical symptoms and imaging manifestations of neurocysticercosis(NCC)are very different,and the difficulty and delay of clinical diagnoses may lead to an increase in mortality and disability.Rapid and accurate pathogen identification is important for the treatment of these patients.Metagenomic next-generation sequencing(mNGS)is a powerful tool to identify pathogens,especially in infections that are difficult to identify by conventional methods.CASE SUMMARY A 43-year-old male patient was admitted due to a recurrent headache for a few months.Imaging examinations showed hydrocephalus and cystic lesions,which were considered to be a central nervous system infection,but no etiology was found by routine examination.mNGS of the cerebrospinal fluid revealed high Taenia solium reads,and the positive results of a cysticercosis antibody test confirmed the infection.Combined with the patient’s clinical manifestations,the etiological evidence,and the imaging manifestation,the patient was finally diagnosed with NCC and he was prescribed dexamethasone,albendazole,neurotrophic drugs,and intracranial pressure reduction therapy.The headaches disappeared after anti-parasite treatment,and no associated symptoms recurred prior to the three-and six-month follow-up.CONCLUSION As an accurate and sensitivity detection method,mNGS can be a reliable approach for the diagnosis of NCC.

关 键 词：NEUROCYSTICERCOSIS Metagenomic next-generation sequencing Taenia solium Case report 

分 类 号：R532.33[医药卫生—内科学]