小剂量氨磺必利联合米氮平治疗老年难治性抑郁症的效果观察  

EFFECT OF LOW DOSES OF AMISULPRIDE AND MIRTAZAPINE IN THE TREATMENT OF SENILE REFRACTORY DEPRESSION

作　　者：杨丽娟[1] 王志广[1] YANG Li-juan;WANG Zhi-guang(Linyi City Mental Health Center,Linyi,China 276000)

机构地区：[1]临沂市精神卫生中心,山东临沂276000

出　　处：《山东医学高等专科学校学报》2023年第4期257-259,共3页Journal of Shandong Medical College

摘　　要：目的探讨老年难治性抑郁症的治疗方法。方法将80例老年难治性抑郁症患者随机分为两组,各40例。对照组给予米氮平,研究组加用氨磺必利。比较两组的治疗效果及安全性。结果研究组有效率为95%,高于对照组的77.50%(χ^(2)=5.17,P=0.023);治疗后,两组HAMD、HAMA量表及GQOLI74问卷各维度评分改善程度均优于对照组(t=3.93~7.04,P<0.01);两组不良反应发生率比较无统计学意义(χ^(2)=0.18,P=0.671)。结论小剂量氨磺必利联合米氮平能够改善老年难治性抑郁症患者的临床症状,且安全可靠。Objective To explore the treatment methods for refractory depression in the elderly.Meth-ods 80 elderly patients with refractory depression were randomly divided into two groups,each with 40 ca-ses.The control group was given mirtazapine,and the research group was given low doses of amisulpride and mirtazapine.The curative effect and safety between the two groups were compared.Results The effec-tive rate of the research group was 95%,higher than 77.50%of the control group(χ^(2)=5.17,P=0.023);After treatment,the improvement degrees of HAMD and HAMA scales and the scores of GQOLI74 ques-tionnaires in the research group was all higher than those in the control group(t=3.93-7.04,P<0.01);No significant difference in the incidence of adverse reactions was found between the two groups(χ^(2)=0.18,P=0.671).Conclusion Low doses of amisulpride and mirtazapine can improve the clinical symptoms of elderly patients with refractory depression.

关 键 词：米氮平 氨磺必利 难治性抑郁症 

分 类 号：R971[医药卫生—药品]