胶原基生物材料在医学美容领域的研究进展  

Collagen-based Biomaterials with Applications in Medical Cosmetology:a Review

作　　者：冯荣欣 但年华[1,2] 陈一宁 但卫华[1,2] FENG Rongxin;DAN Nianhua;CHEN Yining;DAN Weihua(Key Laboratory of Leather Chemistry and Engineering,Ministry of Education,Sichuan University,Chengdu 610065,China;National Engineering Research Center for Leather Cleaning Technology,Chengdu 610065,China)

机构地区：[1]四川大学皮革化学与工程教育部重点实验室,成都610065 [2]制革清洁技术国家工程研究中心,成都610065

出　　处：《材料导报》2023年第14期244-252,共9页Materials Reports

基　　金：皮革化学与工程教育部重点实验室(四川大学)开放课题基金(SCU2021D005);国家自然科学基金(32101081);中央高校基本科研业务费专项资金(专职博士后)(20826041E4156)。

摘　　要：胶原是哺乳动物体内含量最多的蛋白质,在人体皮肤内的含量约为70%,是细胞外基质的主要成分,对皮肤的弹性、光泽、毛孔和水分等具有重要影响。作为天然高分子材料,胶原具有抗原性低、可吸收降解、美白保湿和填充修复等特性,基于天然胶原、水解胶原和重组人源胶原开发研制的产品可以满足不同患者、不同病症的治疗需求,已被广泛用于医学整形美容领域。纯胶原的湿热稳定性、耐酶解性和力学性能较差,将其与天然高分子材料共混制备复合材料可以弥补单一组分的不足,兼具多种材料的优势,胶原蛋白的复合改性是胶原基生物医用材料的研究热点之一。本文介绍了胶原蛋白、水解胶原和重组人源胶原的结构与性能,分析了胶原基复合材料对纯胶原材料缺陷的改善机理,列举了胶原基生物材料在注射医美、人工皮肤、美容敷贴和日用化妆品领域的应用进展,指出了胶原基材料目前存在的问题及今后的发展前景,以期为胶原基生物材料在医学美容领域的产品开发和临床应用提供参考。Collagen is the most abundant protein in mammals,accounting for about 70%of human skin.It is also the main component of the extracellular matrix,exerting an important impact on skin elasticity,gloss,pores,and moisture.As a natural polymer material,collagen has the characteristics of low antigenicity,absorbability,degradability,whitening,moisturizing,and filling repair.Products developed based on natural collagen,hydrolyzed collagen,and recombinant human collagen can meet the treatment needs of different patients and different diseases.In addition,the products have been widely used in the field of plastic and aesthetic medicine.While pure collagen has poor hydrothermal stability,enzymatic hydrolysis resistance,and mechanical properties,blending it with natural polymer materials to prepare composites can make up for the shortcomings of a single component and combine the advantages of multiple materials.This constitutes one of the research hotspots of collagen-based biome-dical materials.In this study,the research progress of collagen in the field of medical cosmetology at home and abroad was described.The molecular structures,preparation methods,and functional properties of collagen,hydrolyzed collagen,and recombinant human collagen were introduced.The performance improvement and mechanism of collagen composites for raw material defects of pure collagen materials were analyzed.The applications of collagen-based biomaterials in injection medical beauty,artificial skin,collagen dressing,and daily cosmetics were listed.The existing problems with collagen-based materials and their future development prospects were pointed out,in order to provide references for the development and clinical applications of collagen-based biological materials in the field of medical cosmetology.

关 键 词：胶原蛋白 重组人源胶原 生物材料 复合材料 人工皮肤 医学美容 

分 类 号：R318.08[医药卫生—生物医学工程]