中空介孔硅基双重响应型药物缓释载体制备及性能研究  

Preparation and Properties of Hollow Mesoporous Silica-based Drug Controlled Release Carrier with Dual Response of pH and Redox

作　　者：葛勇琪 孙晓然 尚宏周 杨梦然 翁志超 李佳睿 孙影 GE Yongqi;SUN Xiaoran;SHANG Hongzhou;YANG Mengran;WENG Zhichao;LI Jiarui;SUN Ying(College of Chemical Engineering,North China University of Science and Technology,Tangshan 063210,China;College of Materials Science and Engineering,North China University of Science and Technology,Tangshan 063210,China;College of Pharmacy,North China University of Science and Technology,Tangshan 063210,China;School of Basic Medical Sciences,North China University of Science and Technology,Tangshan 063210,China)

机构地区：[1]华北理工大学化学工程学院,河北唐山063210 [2]华北理工大学材料科学与工程学院,河北唐山063210 [3]华北理工大学药学院,河北唐山063210 [4]华北理工大学基础医学院,河北唐山063210

出　　处：《化学与生物工程》2023年第7期18-22,共5页Chemistry & Bioengineering

基　　金：河北省教育厅项目(JYG2019003);唐山市基础创新团队项目(21130201D);河北省大学生创新创业训练计划项目(XX20201891)。

摘　　要：以介孔二氧化硅纳米颗粒(MSN)为内核,在其表面修饰巯基、带有二硫键的羧基链和壳聚糖(CS),制备了具有pH和氧化还原双重响应的介孔二氧化硅纳米药物载体CS-ss-MSN,采用SEM、TEM、IR、XRD和N2吸附-脱附分析对其进行了表征,并对其载药性能及负载槲皮素(QUE)的载药体系QUE@CS-ss-MSN的释药性能进行了评价。结果表明,CS-ss-MSN呈均匀球形,粒径约为45~50 nm,平均孔径为2.06 nm;最佳载药时间为420 min、载药温度为30℃;当pH值为5.5、谷胱甘肽(GSH)含量为20 mmol·L^(-1)时,累积释药率最高,为45%。QUE@CS-ss-MSN具有良好的pH和氧化还原响应性,能够实现药物的控制释放。Using mesoporous silica nanoparticles(MSN)as a core,we prepared the mesoporous silica nanodrug carrier CS-ss-MSN with dual response of pH and redox by modifying sulfhydryl group,carboxyl chain with disulfide bond,and chitosan(CS)on the surface of mesoporous silica.Moreover,we characterized the carrier CS-ss-MSN by SEM,TEM,IR,XRD,and N 2 adsorption-desorption analysis,and evaluated its loading property and releasing property of drug delivery system QUE@CS-ss-MSN loaded with quercetin(QUE).The results show that CS-ss-MSN is uniform spherical with the diameter of about 45-50 nm and the average pore size of 2.06 nm.The optimal loading time is 420 min,and the loading temperature is 30℃.When the pH value is 5.5 and the GSH content is 20 mmol·L^(-1),the cumulative drug release rate can reach the highest of 45%.The system QUE@CS-ss-MSN has good pH and redox responsiveness,which can realize controlled release of drugs.

关 键 词：PH响应 氧化还原响应 介孔二氧化硅 药物释放 

分 类 号：TQ127.2[化学工程—无机化工] TQ460.4