中药单体抗乳腺癌作用机制进展  

Research progress on mechanism of anti⁃breast cancer action of Chinese herbal monomers

作　　者：张梦瑶 雷碧黠 解伟 梁蓓蓓[2] 李博华 ZHANG Mengyao;LEI Bixia;XIE Wei;LIANG Beibei;LI Bohua(Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Shanghai University of Medicine&Health Sciences,Shanghai 201318,China)

机构地区：[1]上海中医药大学,上海201203 [2]上海健康医学院,上海201318

出　　处：《上海中医药杂志》2023年第6期26-40,共15页Shanghai Journal of Traditional Chinese Medicine

基　　金：上海市卫健委科研项目(20214Y0516);上海市教委“晨光计划”项目(18-CG72)。

摘　　要：乳腺癌是女性常见的恶性肿瘤,中药对其有较好的治疗作用。通过梳理相关文献,从化合物属性(黄酮类、萜类、生物碱类、其他)角度归纳整理中药单体抗乳腺癌的作用机制,以期为中医药治疗乳腺癌的研究工作及新药的研发提供参考。中药单体抗乳腺癌的主要机制涉及细胞毒性的直接杀伤作用,调节肿瘤免疫微环境,增强靶向药物治疗敏感性及辅助放射治疗、化学疗法等方面。部分中药单体的生物毒性、成药性等问题亟待解决,具有开发潜力的中药单体作用机制、衍生物开发、药代动力学、给药方式、用药安全性等研究数据亦有待补充。Breast cancer is a common malignant tumor in women,and the therapeutic effects of traditional Chinese herbal medicines(TCHMs)are satisfactory.By reviewing relevant literature,we summarized the mechanism of action of Chinese herbal monomers against breast cancer in terms of compound properties(flavonoids,terpenoids,alkaloids and others),with the aim of providing a reference for the research on traditional Chinese medicine for breast cancer treatment and the development of new drugs.The main mechanisms of Chinese herbal monomers against breast cancer mainly involve direct cytotoxicity,regulation of the tumor immune microenvironment,increasing sensitivity to targeted drug therapy,and suppor radiotherapy and chemotherapy.Some issues,such as the biological toxicity and developability of certain Chinese herbal monomers,need to be addressed.Research data on the mechanisms of action,development of derivatives,pharmacokinetics,administration methods,and drug safety of Chinese herbal monomers with development potential also need to be supplemented.

关 键 词：乳腺癌 中药单体 中医药疗法 黄酮 生物碱 多糖 抗肿瘤 

分 类 号：R285[医药卫生—中药学]