针刺调节阿尔茨海默病β⁃淀粉样蛋白机制的研究进展  

Research progress on mechanism of acupuncture regulating amyloid⁃βin Alzheimer's disease

作　　者：杨茜雯 傅勤慧[1] 裴建[1] YANG Qianwen;FU Qinhui;PEI Jian(Department of Acupuncture and Moxibustion,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院针灸科,上海200032

出　　处：《上海中医药杂志》2023年第7期88-93,共6页Shanghai Journal of Traditional Chinese Medicine

基　　金：上海市科委科技计划项目(18401970500,22Y11922900);上海市中医药管理局上海市进一步加快中医药传承创新发展三年行动计划项目(ZY〔2021-2023〕-0209-10);上海申康医院发展中心促进市级医院临床技能与临床创新能力三年行动计划项目(SHDC2020CR3091B)。

摘　　要：综述针刺调节阿尔茨海默病(AD)β-淀粉样蛋白(Aβ)机制的研究进展。Aβ斑块的形成、沉积与清除在AD的病理机制中发挥着重要作用。针刺通过调控Aβ切割、神经胶质细胞、线粒体及自噬系统、Tau蛋白磷酸化及神经原纤维缠结(NFT)形成,可减少Aβ的产生、沉积以及促进Aβ的清除,进而发挥神经功能保护作用。This paper reviews the research progress on the mechanism of acupuncture regulating amyloid-β(Aβ)in Alzheimer's disease(AD).The production,deposition and clearance of Aβplaques play an important role in the pathological mechanism of AD.By regulating Aβcleavage,neuroglia,mitochondrial and autophagic systems,Tau protein phosphorylation and neurofibrillary tangles(NFT)formation,acupuncture can reduce Aβproduction,deposition and promote Aβclearance,thus exerting neuroprotective effects.

关 键 词：阿尔茨海默病 Β-淀粉样蛋白 生物标志物 针刺 研究进展 

分 类 号：R245[医药卫生—针灸推拿学]