CeRNA网络在类风湿关节炎的炎症细胞中的作用  

Role of ceRNA network in inflammatory cells of rheumatoid arthritis

作　　者：何晓宇 何豪华 张妍 吴天宇 陈永杰 唐承志 夏天 张小楠 谢长好[1,5] HE Xiaoyu;HE Haohua;ZHANG Yan;WU Tianyu;CHEN Yongjie;TANG Chengzhi;XIA Tian;ZHANG Xiaonan;XIE Changhao(Department of Rheumatology and Immunology,First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004;Department of Clinical Medicine,Bengbu Medical College,Bengbu Anhui 233030;School of Public Health,Bengbu Medical College,Bengbu Anhui 233030;Key Laboratory of Cardiovascular and Cerebrovascular Diseases,Bengbu Medical College,Bengbu Anhui 233030;Anhui Province Key Laboratory of Immunology in Chronic Diseases,Bengbu Medical College,Bengbu Anhui 233030,China)

机构地区：[1]蚌埠医学院第一附属医院风湿免疫科,安徽蚌埠233004 [2]蚌埠医学院临床医学系,安徽蚌埠233030 [3]蚌埠医学院公共卫生学院,安徽蚌埠233030 [4]蚌埠医学院心脑血管疾病基础与临床重点实验室,安徽蚌埠233030 [5]蚌埠医学院慢性疾病免疫学基础与临床安徽省重点实验室,安徽蚌埠233030

出　　处：《中南大学学报（医学版）》2023年第5期750-759,共10页Journal of Central South University ：Medical Science

基　　金：安徽省自然科学基金(2108085MH258);国家级大学生创新训练项目(202210367059);安徽省大学生创新训练项目(S202110367076);蚌埠医学院研究生创新计划(Byycx22024,Byycx22028)。

摘　　要：类风湿关节炎(rheumatoid arthritis,RA)是一种由炎症细胞导致的慢性炎症性自身免疫病,参与RA的炎症细胞包括成纤维样滑膜细胞、巨噬细胞、CD4^(+)T淋巴细胞、B淋巴细胞、破骨细胞和软骨细胞等。各种炎症细胞之间密切的相互作用导致免疫反应失调,使炎症细胞的mRNA表达紊乱,产生促炎细胞因子,激活抗原特异性T/B淋巴细胞应答,促进自身抗体的产生,是RA的重要致病因素。竞争性内源RNA(competing endogenous RNA,ceRNA)能够通过竞争性地结合miRNA来调节mRNA的表达,与之相关的ceRNA网络被发现参与调控RA炎症细胞的增殖、凋亡、侵袭以及炎症因子释放等异常生物学过程。了解ceRNA网络在6种RA常见炎症细胞中的作用有助于为进一步研究RA的发病机制提供新思路,也可为发现新的生物标志物和有效治疗靶点提供理论基础。Rheumatoid arthritis(RA)is a chronic inflammatory autoimmune disease caused by inflammatory cells.Various inflammatory cells involved in RA include fibroblast-like synoviocytes,macrophages,CD4^(+)T-lymphocytes,B lymphocytes,osteoclasts and chondrocytes.The close interaction between various inflammatory cells leads to imbalance of immune response and disorder of the expression of mRNA in inflammatory cells.It helps to drive production of pro-inflammatory cytokines and stimulate specific antigen-specific T-and B-lymphocytes to produce autoantibodies which is an important pathogenic factor for RA.Competing endogenous RNA(ceRNA)can regulate the expression of mRNA by competitively binding to miRNA.The related ceRNA network is a new regulatory mechanism for RNA interaction.It has been found to be involved in the regulation of abnormal biological processes such as proliferation,apoptosis,invasion and release of inflammatory factors of RA inflammatory cells.Understanding the ceRNA network in 6 kinds of RA common inflammatory cells provides a new idea for further elucidating the pathogenesis of RA,and provides a theoretical basis for the discovery of new biomarkers and effective therapeutic targets.

关 键 词：竞争性内源RNA网络 长链非编码RNA 环状RNA 微RNA 类风湿关节炎 炎症细胞 

分 类 号：R593.22[医药卫生—内科学]