中医综合疗法治疗糖尿病周围神经病变临床研究  

Clinical Study on Comprehensive Therapy of Traditional Chinese Medicine in Treatment of Diabetic Peripheral Neuropathy

作　　者：林称心 李光智[1] 林如意[1] LIN Chenxin;LI Guangzhi;LIN Ruyi(Hainan Hospital of Traditional Chinese Medicine,Haikou 571100,China)

机构地区：[1]海南省中医院,海南海口571100

出　　处：《山东中医杂志》2023年第7期679-683,共5页Shandong Journal of Traditional Chinese Medicine

基　　金：海南省卫生健康行业科研项目(编号:21A200392)。

摘　　要：目的:观察加味芍药甘草汤合桃红四物汤联合穴位贴敷、中药浴足治疗糖尿病周围神经病变的临床疗效。方法:选择糖尿病周围神经病变患者90例,按随机数字表法分为对照组、治疗1组、治疗2组各30例。三组患者均予基础降糖治疗,在此基础上,对照组患者采用甲钴胺治疗,治疗1组患者采用加味芍药甘草汤合桃红四物汤治疗,治疗2组患者采用加味芍药甘草汤合桃红四物汤联合穴位贴敷、中药浴足治疗,三组均连续治疗12周(1个疗程)。比较三组患者多伦多临床评分系统(TCSS)评分、震动感觉阈值、神经传导速度、临床疗效、中医症状积分、氧化应激水平。结果:治疗后,三组患者TCSS评分、震动感觉阈值、中医症状积分均较治疗前降低(P<0.05),腓总神经、正中神经传导速度均较治疗前加快(P<0.05),血清丙二醛(MDA)、晚期糖基化终末产物(AGE)水平均较治疗前降低(P<0.05),血清超氧化物歧化酶(SOD)水平较治疗前升高(P<0.05)。组间比较,治疗2组患者治疗后上述指标水平均优于对照组和治疗1组(P<0.05),治疗总有效率高于对照组和治疗1组,临床疗效优于对照组和治疗1组(P<0.05)。结论:加味芍药甘草汤合桃红四物汤联合穴位贴敷、中药浴足治疗糖尿病周围神经病变能改善患者临床症状,促进神经功能恢复,调节机体氧化应激水平,疗效确切。Objective:To observe the clinical curative efficacy of Modified Shaoyao Gancao Decoction(加味芍药甘草汤)and Taohong Siwu Decoction(桃红四物汤)combined with acupoint application and foot bath with Chinese medicine in the treatment of diabetic peripheral neuropathy(DPN).Methods:A total of 90 patients with DPN were divided into control group,treatment group 1 and treatment group 2 according to the random number table method,with 30 cases in each group.On the basis of basic glucose-lowering treatment given to all the three groups,patients in the control group were treated with methylcobalamin,patients in the treatment group 1 were treated with Modified Shaoyao Gancao Decoction and Taohong Siwu Decoction,and patients in the treatment group 2 were treated with Modified Shaoyao Gancao Decoction and Taohong Siwu Decoction combined with acupoint application and foot bath.All the three groups were treated for 12 weeks(1 course of treat-ment).The Toronto Clinical Scoring System(TCSS)score,vibration sensation threshold,nerve conduction velocities,clinical curative efficacy,traditional Chinese medicine(TCM)symptom scores,and oxidative stress level were compared among the three groups.Results:After treatment,in the patients in all the three groups,the TCSS score,vibration sensation threshold,and TCM symptom score were lower than those before treatment(P<0.05),the conduction velocities of common peroneal nerve and median nerve were faster than those before treatment(P<0.05),the levels of serum malondialdehyde(MDA)and advanced glycation end products(AGE)were lower than those before treatment(P<0.05),and the level of serum superoxide dismutase(SOD)was higher than that before treatment(P<0.05).In comparison among the three groups,the levels of the above indicators in treatment group 2 were better than those in the control group and treatment group 1 after treatment(P<0.05),and the total effective rate in treatment group 2 was higher than that in the control group and treatment group 1,indicating the clinical curative e

关 键 词：糖尿病周围神经病变 加味芍药甘草汤 桃红四物汤 穴位贴敷 中药浴足 多伦多临床评分系统 震动感觉阈值 氧化应激 

分 类 号：R259[医药卫生—中西医结合]