蒲公英研究进展及质量标志物预测分析  

Research Progress of Pugongying(Taraxaci Herba)and Predictive Analysis of Quality Markers

作　　者：孙绍欣 王信[2] 林丽[3] 李健[2] SUN Shaoxin;WANG Xin;LIN Li;LI Jian(Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Jinan Hospital of Traditional Chinese Medicine,Jinan 250012,China)

机构地区：[1]山东中医药大学,山东济南250355 [2]山东中医药大学附属医院,山东济南250014 [3]济南市中医医院,山东济南250012

出　　处：《山东中医杂志》2023年第7期773-780,共8页Shandong Journal of Traditional Chinese Medicine

基　　金：国家“重大新药创制”科技重大专项(编号:2017ZX09301058);山东中医药科技发展计划项目(编号:2015-490,2015-309);2018年全国中药特色技术传承人才培训项目(编号:T20184828005)。

摘　　要：通过对蒲公英化学成分、药理作用及质量控制研究现状进行综述,发现蒲公英含有黄酮类、酚酸类、萜类等多种有效成分,具有抗炎、抑菌、抗氧化、抗肿瘤等药理作用,在药品和食品应用领域具有广阔的开发利用前景。基于中药质量标志物概念,从成分特有性、传统功效、成分有效性、成分可测性和药动学等几个方面对蒲公英质量标志物进行预测分析,认为单咖啡酰酒石酸、绿原酸、咖啡酸、菊苣酸、木犀草素、木犀草苷可作为蒲公英药材的质量标志物。参考文献71篇。Through reviewing the research status of chemical constituents,pharmacological effects and quality control of Pugongying(Taraxaci Herba),it is found that Taraxaci Herba contains multiple effective constituents,including flavonoids,phenolic acids,terpenoids,etc.,and has various pharmacological effects,including anti-inflammation,anti-bacteria,anti-oxidation,anti-tumor,etc.,so it has broad prospects for development and utilization in the field of medicine and food application.Based on the concept of quality markers of Chinese medicinals,the quality markers of Taraxaci Herba were predicted and analyzed from the following aspects:constituent specificity,traditional efficacy,effectiveness of constituents,constituent measurability and pharmacokinetics.It is concluded that caftaric acid,chlorogenic acid,caffeic acid,chicoric acid,digitoflavone and galuteolin can be used as quality markers of Taraxaci Herba.There are 71 references.

关 键 词：蒲公英 化学成分 药理作用 质量标志物 研究进展 

分 类 号：R284.1[医药卫生—中药学] R285[医药卫生—中医学]