基于数据挖掘分析糖尿病肾病证候及用药规律  

Analysis of Syndrome and Medication Regularity of Diabetic Kidney Disease Based on Data Mining

作　　者：周婷[1] 屈凯 陈志永 许建秦 刘厚利 何莉 刘双 刘月梅 秦登 ZHOU Ting;QU Kai;CHEN Zhiyong;XU Jianqin;LIU Houli;HE Li;LIU Shuang;LIU Yuemei;QIN Deng(Shaanxi University of Chinese Medicine,Xianyang 710042,China;Shaanxi Hospital of Traditional Chinese Medicine,Xi’an 710003,China;Shaanxi Academy of Traditional Chinese Medicine,Xi’an 710003,China)

机构地区：[1]陕西中医药大学,陕西咸阳710042 [2]陕西省中医医院,陕西西安710003 [3]陕西省中医药研究院,陕西西安710003

出　　处：《山东中医药大学学报》2023年第4期439-445,共7页Journal of Shandong University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(编号:81603454);国家中医药管理局中医药科学技术研究专项课题项目(编号:GZY-KJS-2021-005);陕西省中医药管理局中西医结合临床协作创新项目(编号:2020-ZXY-005);陕西中医药大学校级科研课题创新项目(编号:2021CX10)。

摘　　要：目的:应用数据挖掘技术分析总结相关文献中糖尿病肾病的证候及用药规律。方法:运用中国知网(CNKI)、维普资讯中文期刊服务平台,搜集2015年1月1日至2020年12月31日治疗糖尿病肾病的医案,提取用药信息,通过Microsoft Excel 2019建立数据库整理归纳数据,总结糖尿病肾病的证候分布情况、药物治疗分布情况以及药物组合关联规则等。结果:共检索相关文献923篇,根据证候分布情况,病位类证候要素主要为肾、脾、肝、肺、心等;病性类证候要素主要为瘀血、痰浊、阴虚、气虚、浊毒等。根据药物治疗分布情况,四气主要为平、温、寒、微温、微寒,五味多为甘、苦、辛、酸、淡、微苦,且归于肝、脾、肾、肺、心、胃、膀胱、大肠经。核心药物以黄芪、茯苓、山药、山茱萸、丹参等50味中药为主,可归纳为补虚药、活血化瘀药、清热药、利湿药、收涩药;药物组合关联规则显示,丹参、山药、山茱萸、茯苓均与黄芪联系密切。结论:益气养阴、活血通络法为糖尿病肾病主要治法,此为后续进一步开展临床研究提供了数据支撑。Objective:To analyze and summarize the syndrome and medication regularity of diabetic kidney disease in related literatures by data mining technique.Methods:The medical records of diabetic kidney disease from January 1,2015 to December 31,2020 were collected by using the China National Knowledge Infrastructure(CNKI)and Weipu Journal Resource Integration Service Platform,and the medi-cation information was extracted.The database was established by Microsoft Excel 2019 to sort out and generalize the data,and the characteristics of syndrome distribution,medication distribution and association rules of medicinal combination of diabetic kidney disease were summarized.Results:A total of 923 relevant literatures were retrieved.According to the distribution of syndromes,the syndrome elements of disease location were mainly kidney,spleen,liver,lung,heart,etc.The syndrome elements of disease nature were mainly blood stasis,phlegm turbidity,yin deficiency,qi deficiency,turbid toxin,etc.According to the distribution of medication,the four properties were mainly neutral,warm,cold,slightly warm and slightly cold,and the five flavors were sweet,bitter,acrid,sour,bland and slightly bitter,which were attributed to liver,spleen,kidney,lung,heart,stomach,bladder and large intestine in channel tropism.It was determined that total 50 kinds of traditional Chinese medicinals,such as Huangqi(Astragali Radix),Fuling(Poria),Shanyao(Dioscoreae Rhizoma),Shanzhuyu(Corni Fructus)and Danshen(Salviae Miltiorrhizae Radix Et Rhizoma)were the main core medicinals,which could be summarized as medicinals for tonifying deficiency,medicinals for activating blood and resolving blood stasis,medicinals for clearing heat,medicinals for draining dampness and astringent medicinals.According to the association rules of medicinal combination,Danshen,Shanyao,Shanzhuyu and Fuling are closely related to Huangqi.Conclusions:Supplementing qi and nourishing yin,activating blood and dredging collaterals are the main treatment methods for diabetic kidney disease,whic

关 键 词：文献研究 糖尿病肾病 证候规律 用药规律 益气养阴 活血通络 数据挖掘 

分 类 号：R259[医药卫生—中西医结合]