中国内脏肥胖指数对成人2型糖尿病并发代谢相关脂肪性肝病的预测效能  

Predictive efficacy of Chinese visceral adiposity index on MAFLD in adults with type 2 diabetes mellitus

作　　者：孙婷 马言 田高鹏 谢晶晶 石兴文 甄东户[2] SUN Ting;MA Yan;TIAN Gaopeng;XIE Jingjing;SHI Xingwen;ZHEN Donghu(The First School of Clinical Medicine of Lanzhou University,Lanzhou 730000,China;不详)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]兰州大学第一医院内分泌科

出　　处：《山东医药》2023年第20期20-24,共5页Shandong Medical Journal

基　　金：上海市医药卫生发展基金会糖尿病临床研究项目(I期10研究);国家标准化代谢性疾病管理中心专项研究基金项目(2018-mmczxjj-3);甘肃省自然科学基金项目(21JR1RA096);甘肃省内分泌疾病临床医学研究中心(20JR10FA667);兰州大学第一医院院内基金项目(ldyyyn2015-22)。

摘　　要：目的 观察成人2型糖尿病(T2DM)并发代谢相关脂肪性肝病(MAFLD)患者中国内脏肥胖指数(CVAI)变化,并分析CVAI对成人T2DM并发MAFLD的预测效能。方法 成人T2DM患者3 163例,根据腹部超声检查结果分为MAFLD组1 778例、非MAFLD组1 385例。测算并比较两组CVAI,比较不同CVAI水平T2DM患者MAFLD的患病率,采用Logistic回归分析T2DM患者并发MAFLD的影响因素及不同CVAI水平T2DM患者并发MAFLD的风险。采用受试者工作特征(ROC)曲线分析CVAI对T2DM患者并发MAFLD的预测效能。结果 MAFLD组CVAI高于非MAFLD组(P<0.01)。随着CVAI升高,MAFLD患病率逐渐升高。CVAI是T2DM患者并发MAFLD的影响因素之一。调整混杂因素后,高水平的CVAI仍可导致MAFLD患病风险升高。CVAI预测T2DM患者并发MAFLD的ROC曲线下面积为0.634,截断值为123.41,灵敏度为62.3%,特异度为57.1%,且CVAI对女性T2DM患者并发MAFLD的预测效能优于男性患者。结论 T2DM并发MAFLD患者的CVAI显著升高,CVAI是成人T2DM并发MAFLD的影响因素,对MAFLD有一定预测效能。Objective To observe the changes in Chinese visceral adiposity index(CVAI) in adults with type 2 diabetes mellitus(T2DM) complicated with metabolic-associated fatty liver disease(MAFLD) and to analyze the predictive efficacy of CVAI on the occurrence of MAFLD in adults with T2DM.Methods A total of 3 163 adults with T2DM were included in the study.According to the abdominal ultrasound results,they were divided into the MAFLD group(1 778 cases) and the non-MAFLD group(1 385 cases).CVAI was calculated and compared between the two groups,and the prevalence of MAFLD in T2DM patients at different CVAI levels was compared.Logistic regression analysis was used to identify the influencing factors for the occurrence of MAFLD in T2DM patients and the risk of MAFLD in T2DM patients at different CVAI levels.The predictive efficacy of CVAI on the occurrence of MAFLD in T2DM patients was analyzed using receiver operating characteristic(ROC) curve.Results The CVAI in the MAFLD group was higher than that in the non-MAFLD group(P<0.01).As CVAI increased,the prevalence of MAFLD gradually increased.CVAI was one of the influencing factors for the occurrence of MAFLD in T2DM patients.After adjusting for confounding factors,the high level of CVAI still increased the risk of MAFLD.The area under the ROC curve of CVAI in predicting the occurrence of MAFLD in T2DM patients was 0.634(P<0.01),with a cut-off value of 123.41,sensitivity of 62.3%,specificity of 57.1%;the predictive efficacy of CVAI for MAFLD in female T2DM patients was better than that in male patients.Conclusion CVAI significantly increases in T2DM patients with MAFLD,and CVAI is an influencing factor for the occurrence of MAFLD in adults with T2DM,showing a certain predictive efficacy for MAFLD.

关 键 词：中国内脏肥胖指数 2型糖尿病 代谢相关脂肪性肝病 

分 类 号：R587.1[医药卫生—内分泌]