心肌细胞衰老在心血管疾病中的研究进展  

Research progress of cardiomyocyte senescence in cardiovascular diseases

作　　者：王磊[1,2] 康品方[1,2] 吴士礼[1] Wang Lei;Kang Pinfang;Wu Shili(Department of cardiovascular,the first affiliated hospital of Bengbu Medical College,Bengbu,Anhui,233000,China;basic and clinical translational laboratory,Bengbu Medical College)

机构地区：[1]蚌埠医学院第一附属医院心血管科,安徽蚌埠233000 [2]蚌埠医学院心脑血管基础与临床转化实验室

出　　处：《齐齐哈尔医学院学报》2023年第11期1039-1044,共6页Journal of Qiqihar Medical University

基　　金：国家自然科学基金资助项目(81970313);安徽省高校优秀青年基金(2022AH030141)。

摘　　要：越来越多的研究表明,心血管疾病的风险随着年龄的增加、细胞的衰老而增加,细胞衰老是一种不可逆的细胞周期停滞状态,心肌细胞作为终末分化细胞,其衰老的标志是通过各种功能下降来描述的。各种类型的细胞衰老都可能引起相关心血管疾病的发生。本文主要概述心肌细胞衰老机制及其与相关心血管疾病的联系,以及以心肌细胞衰老为靶点治疗相关心血管疾病的前景。A growing body of research has shown that the risk of cardiovascular disease increases with age due to cellular senescence.Cellular senescence is an irreversible state of cell cycle arrest.As terminally differentiated cells,the markers of senescence of cardiomyocytes are described by various functional declines.Various types of cell senescence may cause the occurrence of related cardiovascular diseases.In this paper,we summarize the mechanism of cardiomyocyte senescence and its relationship with cardiovascular diseases,as well as the prospect of targeting cardiomyocyte senescence in the treatment of cardiovascular diseases..

关 键 词：心肌细胞衰老 心血管疾病 自噬 氧化应激 

分 类 号：R54[医药卫生—心血管疾病]