凝血指标与血细胞参数在2型糖尿病血管病变中的临床价值  

Clinical Value of Coagulation Index and Blood Cell Parameters in Type 2 Diabetic Vascular Disease

作　　者：刘文俊[1] 黄慧萍 钟秋连[1] LIU Wenjun;HUANG Huipin;ZHONG Qiulian(Department of Clinical Laboratory,Guangxi Zhuang Autonomous Region People's Hospital(Guangxi Academy of Medical Sciences),Nanning,Guangxi Zhuang Autonomous Region,530021 China)

机构地区：[1]广西壮族自治区人民医院(广西医学科学院)检验科,广西南宁530021

出　　处：《糖尿病新世界》2023年第8期10-13,共4页Diabetes New World Magazine

基　　金：广西壮族自治区卫生健康委员会自筹经费项目(Z2016629,Z-A20220129)。

摘　　要：目的探讨凝血指标和血细胞参数在2型糖尿病合并血管病变中的临床价值。方法选取2018年1月—2021年7月在广西壮族自治区人民医院就诊的2型糖尿病患者482例及健康体检者100名为研究对象,检测血细胞参数、凝血指标并进行统计学分析。结果血管病变组中性粒细胞计数(NEUT)、红细胞分布宽度(RDW)、平均血小板体积(MPV)、粒细胞与淋巴细胞比值(NLR)、血浆纤维蛋白原(FIB)、D-二聚体(D-D)指标高于单纯糖尿病组和对照组,淋巴细胞计数(LY)、血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)指标低于单纯糖尿病组和对照组,差异有统计学意义(P<0.05),单纯糖尿病组NEUT、RDW、MPV、FIB、D-D指标高于对照组,差异有统计学意义(P<0.05),Logistic回归分析显示NEUT、MPV、NLR、FIB为2型糖尿病合并血管病变的危险因素,LY、PT、APTT、TT指标为其保护因素(P<0.05)。结论NEUT、LY、RDW、MPV、NLR、PT、APTT、TT、FIB、D-D与2型糖尿病血管病变密切相关,NEUT、MPV、NLR、FIB指标水平升高和LY、PT、APTT、TT指标水平降低是2型糖尿病患者发生血管病变的危险因素,早期监测这些指标对预防糖尿病血管病变的发生具有一定临床价值。Objective To investigate the clinical value of coagulation index and blood cell parameters in type 2 diabetes mellitus complicated with vascular disease.Methods A total of four hundred and eighty-two patients with type 2 diabetes and one hundred healthy subjects admitted to Guangxi Zhuang Autonomous Region People's Hospital from January 2018 to July 2021were enrolled.Blood cell parameters and coagulation index were detected and analyzed statistically.Results Neutrophil count(NEUT),erythrocyte distribution width(RDW),mean platelet volume(MPV),granulocyte to lymphocyte ratio(NLR),plasma fibrinogen(FIB),D-Dimer(D-D)in the vascular disease group were higher than those in simple diabetic group and control group,thrombin time(LY),prothrombin time(PT),activated partial thrombop-lastin time(APTT),thrombin time(TT)index were lower than those in simple diabetes group and control group,and the difference was statistically significant(P<0.05).NEUT,RDW,MPV,FIB and D-D indexes in simple diabetic group were higher than those in control group,and the difference was statistically significant(P<0.05).Logistic regression analysis showed that NEUT,MPV,NLR and FIB were risk factors for type 2 diabetes mellitus complicated with vascular disease,and LY,PT,APTT and TT were protective factors(P<0.05).Conclusion NEUT,LY,RDW,MPV,NLR,PT,APTT,TT,FIB,D-D are closely related to vascular disease in type 2 diabetes.Increased levels of NEUT,MPV,NLR,FIB and decreased levels of LY,PT,APTT,TTare risk factors for vascular disease in type 2 diabetes patients.Early monitoring of these indicators has certain clinical value to prevent the occurrence of diabetic vascular lesions.

关 键 词：2型糖尿病 凝血指标 血细胞参数 血管病变 

分 类 号：R446.1[医药卫生—诊断学]